catalog number :
MBS9127367
products full name :
LARP7 Polyclonal Antibody
products short name :
[LARP7]
products name syn :
[ALAZS; PIP7S; HDCMA18P]
other names :
[La-related protein 7; La-related protein 7; la-related protein 7; P-TEFb-interaction protein for 7SK stability; La ribonucleoprotein domain family, member 7; La ribonucleoprotein domain family member 7; P-TEFb-interaction protein for 7SK stability; PIP7S]
products gene name :
[LARP7]
other gene names :
[LARP7; LARP7; ALAZS; PIP7S; HDCMA18P; PIP7S]
uniprot entry name :
LARP7_HUMAN
purity :
Affinity Purification
form :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
storage stability :
Store at 4°C. Avoid freeze / thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB: 1:500 - 1:2000
image1 heading :
Western Blot (WB)
other info2 :
Immunogen: A synthetic peptide of human LARP7. Calculated MW: 24kDa/66kDa/67kDa. Observed MW: 80kDa
products categories :
Polyclonal
products description :
This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants.
ncbi summary :
This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
uniprot summary :
LARP7: Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. 2 isoforms of the human protein are produced by alternative splicing. Protein type: RNA-binding. Chromosomal Location of Human Ortholog: 4q25. Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; ribonucleoprotein complex; nucleus. Molecular Function: protein binding; nucleotide binding. Biological Process: RNA processing. Disease: Alazami Syndrome