product summary
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company name :
MyBioSource
product type :
antibody
product name :
TRPM8
catalog :
MBS9127322
quantity :
0.05 mL
price :
200 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry
more info or order :
MyBioSource product webpage
image
image 1 :
MyBioSource MBS9127322 image 1
Western blot analysis of extracts of various cell lines, using TRPM8 antibody at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
product information
catalog number :
MBS9127322
products type :
Antibody
products full name :
TRPM8
products short name :
[TRPM8]
other names :
[Transient receptor potential cation channel subfamily M member 8; Transient receptor potential cation channel subfamily M member 8; transient receptor potential cation channel subfamily M member 8; trp-p8; LTrpC-6; transient receptor melastatin 8; transient receptor potential p8; short form of the TRPM8 cationic channel; long transient receptor potential channel 6; transient receptor potential subfamily M member 8; transient receptor potential cation channel, subfamily M, member 8; Long transient receptor potential channel 6; LTrpC-6; LTrpC6; Transient receptor potential p8; Trp-p8]
products gene name :
[TRPM8]
other gene names :
[TRPM8; TRPM8; TRPP8; LTRPC6; LTRPC6; TRPP8; LTrpC-6; LTrpC6; Trp-p8]
uniprot entry name :
TRPM8_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human
sequence length :
1104
purity :
Affinity Purification
storage stability :
Store at -20 degree C. Avoid freeze/thaw cycles
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: Recombinant funsion protein containing a sequence corresponding to amino acids 980-1104 of human TRPM8
other info2 :
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH 7.3
products categories :
Polyclonal
ncbi gi num :
143811469
ncbi acc num :
NP_076985.4
uniprot acc num :
Q7Z2W7
ncbi mol weight :
Calculated MW: 5kDa/18kDa/79kDa/127kDa. Observed MW: 126kDa
ncbi pathways :
Inflammatory Mediator Regulation Of TRP Channels Pathway (948277); Inflammatory Mediator Regulation Of TRP Channels Pathway (948307); Ion Channel Transport Pathway (187193); Stimuli-sensing Channels Pathway (771568); TRP Channels Pathway (906028); Transmembrane Transport Of Small Molecules Pathway (106572)
uniprot summary :
TRPM8: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Channel, cation; Membrane protein, integral. Chromosomal Location of Human Ortholog: 2q37.1. Cellular Component: endoplasmic reticulum membrane; plasma membrane; integral to membrane; lipid raft; external side of plasma membrane. Molecular Function: protein binding; protein homodimerization activity; calcium channel activity. Biological Process: cellular calcium ion homeostasis; detection of temperature stimulus; thermoception; response to cold; transmembrane transport; protein homotetramerization
size1 :
0.05 mL
price1 :
200 USD
size2 :
0.1 mL
price2 :
275
size3 :
0.2 mL
price3 :
430
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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