catalog number :
MBS9127297
products full name :
QARS Polyclonal Antibody
products short name :
QARS
products name syn :
GLNRS; MSCCA; PRO2195
other names :
Glutamine--tRNA ligase; Glutamine--tRNA ligase; glutamine--tRNA ligase; glutamine-tRNA synthetase; glutaminyl-tRNA synthetase; Glutaminyl-tRNA synthetase; GlnRS
products gene name :
QARS
other gene names :
QARS; QARS; GLNRS; MSCCA; PRO2195; GlnRS
uniprot entry name :
SYQ_HUMAN
reactivity :
Human, Mouse
purity :
Affinity Purification
storage stability :
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
tested application :
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
app notes :
WB: 1:500 - 1:2000. IHC: 1:50 - 1:200. IF: 1:50 - 1:100
other info1 :
Species: Human. Immunogen: Recombinant Protein. Gene ID: 5859
other info2 :
Immunogen: Recombinant protein of human QARS. Calculated Molecular Weight: Refer to figures.
products categories :
Polyclonal
products description :
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants.
ncbi pathways :
Aminoacyl-tRNA Biosynthesis Pathway (83030); Aminoacyl-tRNA Biosynthesis Pathway (424); Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway (413439); Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway (468360); Cytosolic TRNA Aminoacylation Pathway (105981); Gene Expression Pathway (105937); Metabolic Pathways (132956); Mitochondrial TRNA Aminoacylation Pathway (105982); TRNA Aminoacylation Pathway (105980)
ncbi summary :
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
uniprot summary :
QARS: catalyzes the formation of L-glutaminyl-tRNA. Belongs to the class-I aminoacyl-tRNA synthetase family. Protein type: Ligase; EC 6.1.1.18; Mitochondrial; Translation. Chromosomal Location of Human Ortholog: 3p21.31. Cellular Component: mitochondrial matrix; cytoplasm; cytosol. Molecular Function: protein binding; glutamine-tRNA ligase activity; ATP binding. Biological Process: tRNA aminoacylation for protein translation; glutaminyl-tRNA aminoacylation; gene expression; brain development. Disease: Microcephaly, Progressive, With Seizures And Cerebral And Cerebellar Atrophy