ARL13B Polyclonal Antibody | MyBioSource MBS9126992 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ARL13B Polyclonal Antibody

catalog :

MBS9126992

quantity :

0.05 mL

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of extracts of SKOV3 cells, using ARL13B antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

image 2 :

Immunofluorescence analysis of C6 cells using ARL13B antibody (MBS9126992) at dilution of 1:100. Blue: DAPI for nuclear staining.

image 3 :

Immunofluorescence analysis of U-2 OS cells using ARL13B antibody (MBS9126992) at dilution of 1:100. Blue: DAPI for nuclear staining.

product information

catalog number :

MBS9126992

products type :

Antibody

products full name :

ARL13B Polyclonal Antibody

products short name :

[ARL13B]

products name syn :

[ARL13B; ARL2L1; JBTS8; ADP ribosylation factor like GTPase 13B]

other names :

[ADP-ribosylation factor-like protein 13B; ADP-ribosylation factor-like protein 13B; ADP-ribosylation factor-like protein 13B; ARL2-like protein 1; ADP-ribosylation factor-like 2-like 1; ADP-ribosylation factor-like 13B; ADP-ribosylation factor-like protein 2-like 1; ARL2-like protein 1]

products gene name :

[ARL13B]

other gene names :

[ARL13B; ARL13B; JBTS8; ARL2L1; ARL2L1; ARL2-like protein 1]

uniprot entry name :

AR13B_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

428

purity :

Affinity Purification

form :

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

storage stability :

Store at -20°C. Avoid freeze / thaw cycles.

tested application :

Western Blot (WB)

app notes :

Recommended Dilutions: WB 1:500 - 1:2000

image1 heading :

Western Blot (WB)

image2 heading :

Immunofluorescence (IF)

image3 heading :

Immunofluorescence (IF)

image4 heading :

Immunofluorescence (IF)

image4 description :

Immunofluorescence analysis of L929 cells using ARL13B antibody (MBS9126992) at dilution of 1:100. Blue: DAPI for nuclear staining.

other info1 :

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human ARL13B (NP_878899.1).

products categories :

Polyclonal

products description :

This gene encodes a member of the ADP-ribosylation factor-like family. The encoded protein is a small GTPase that contains both N-terminal and C-terminal guanine nucleotide-binding motifs. This protein is localized in the cilia and plays a role in cilia formation and in maintenance of cilia. Mutations in this gene are the cause of Joubert syndrome 8. Alternate splicing results in multiple transcript variants.

ncbi gi num :

115503786

ncbi acc num :

Q3SXY8.1

uniprot acc num :

Q3SXY8

ncbi mol weight :

Observed: 49kDa. Calculated: 36kDa/37kDa/48kDa

ncbi pathways :

ARL13B-mediated Ciliary Trafficking Of INPP5E Pathway (1127508); Assembly Of The Primary Cilium Pathway (1127502); Cargo Trafficking To The Periciliary Membrane Pathway (1127504); Organelle Biogenesis And Maintenance Pathway (1127494)

ncbi summary :

uniprot summary :

ARL13B: Defects in ARL13B are the cause of Joubert syndrome type 8 (JBTS8). JBTS is an autosomal recessive disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermis hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease. Belongs to the small GTPase superfamily. Arf family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: G protein, monomeric; G protein, monomeric, ARF. Chromosomal Location of Human Ortholog: 3q11.1. Cellular Component: intracellular; cilium. Molecular Function: protein binding; GTP binding. Biological Process: formation of radial glial scaffolds; smoothened signaling pathway; dorsal/ventral pattern formation; interneuron migration from the subpallium to the cortex; sensory cilium biogenesis; organelle organization and biogenesis; small GTPase mediated signal transduction; neural tube patterning; cilium biogenesis; heart looping. Disease: Joubert Syndrome 8

size1 :

0.05 mL

price1 :

200 USD

size2 :

0.1 mL

price2 :

275

size3 :

0.2 mL

price3 :

430

more info or order :

MyBioSource product webpage