TCAP Polyclonal Antibody | MyBioSource MBS9126105 product information

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company name :

MyBioSource

product type :

antibody

product name :

TCAP Polyclonal Antibody

catalog :

MBS9126105

quantity :

0.05 mL

price :

200 USD

clonality :

polyclonal

host :

unidentified

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of extracts of various cell lines, using TCAP antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.

product information

catalog number :

MBS9126105

products type :

Antibody

products full name :

TCAP Polyclonal Antibody

products short name :

[TCAP]

products name syn :

[TCAP; CMD1N; CMH25; LGMD2G; T-cap; TELE; telet honin; titin-cap]

other names :

[Telethonin; Telethonin; telethonin; titin cap protein; 19 kDa sarcomeric protein; limb girdle muscular dystrophy 2G (autosomal recessive); titin-cap; Titin cap protein]

products gene name :

[TCAP]

other gene names :

[TCAP; TCAP; TELE; CMD1N; T-cap; LGMD2G; telethonin]

uniprot entry name :

TELT_HUMAN

clonality :

polyclonal

isotype :

IgG

host :

unknown

reactivity :

Mouse, Rat

sequence length :

167

purity :

Affinity Purification

concentration :

1mg/ml

storage stability :

Store at -20 degree C (regular). Avoid freeze / thaw cycles.

tested application :

Western Blot (WB)

app notes :

WB: 1:500 - 1:2000

image1 heading :

Western Blot (WB)

other info1 :

Species: Human. Immunogen: Recombinant Protein. Category: Primary Antibody. Source: Rabbit

other info2 :

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-167 of human TCAP (NP_003664.1). Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

products categories :

Polyclonal

products description :

Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G.

ncbi gi num :

3024716

ncbi acc num :

O15273.1

uniprot acc num :

O15273

ncbi mol weight :

Observed MW: 19kDa. Calculated MW: 19kDa

ncbi pathways :

Muscle Contraction Pathway (106261); Striated Muscle Contraction Pathway (198903); Striated Muscle Contraction Pathway (106262)

ncbi summary :

Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. [provided by RefSeq, Jul 2008]

uniprot summary :

Telethonin: a muscle assembly regulating factor that interacts with the giant kinase titin. Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. Telethonin is found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. Protein type: Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 17q12. Cellular Component: I band; cytosol; Z disc. Molecular Function: protein binding, bridging; protein binding; structural constituent of muscle; titin binding; FATZ binding. Biological Process: adult heart development; skeletal muscle contraction; cardiac muscle hypertrophy; somitogenesis; muscle thin filament assembly; detection of mechanical stimulus; cardiac myofibril assembly; sarcomere organization; muscle filament sliding; muscle thick filament assembly; cardiac muscle fiber development; cardiac muscle morphogensis; sarcomerogenesis; protein complex assembly; otic vesicle formation; cardiac muscle contraction. Disease: Muscular Dystrophy, Limb-girdle, Type 2g; Cardiomyopathy, Dilated, 1n

size1 :

0.05 mL

price1 :

200 USD

size2 :

0.1 mL

price2 :

275

size3 :

0.2 mL

price3 :

430

more info or order :

MyBioSource product webpage