product summary
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company name :
MyBioSource
product type :
antibody
product name :
FRZB Polyclonal Antibody
catalog :
MBS9126066
quantity :
0.05 mL
price :
200 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunocytochemistry
more info or order :
MyBioSource product webpage
image
image 1 :
MyBioSource MBS9126066 image 1
Western blot analysis of extracts of various cell lines, using FRZB antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
image 2 :
MyBioSource MBS9126066 image 2
Immunofluorescence analysis of A549 cells using FRZB antibody. Blue: DAPI for nuclear staining.
product information
catalog number :
MBS9126066
products type :
Antibody
products full name :
FRZB Polyclonal Antibody
products short name :
[FRZB]
products name syn :
[FRE; OS1; FZRB; hFIZ; FRITZ; FRP-3; FRZB1; SFRP3; SRFP3; FRZB-1; FRZB-PEN]
other names :
[Secreted frizzled-related protein 3; Secreted frizzled-related protein 3; secreted frizzled-related protein 3; sFRP-3; frezzled; frizzled homolog-related; frizzled-related protein 1; frizzled-related protein; Frezzled; Fritz; Frizzled-related protein 1; FrzB-1]
products gene name :
[FRZB]
other gene names :
[FRZB; FRZB; FRE; OS1; FZRB; hFIZ; FRITZ; FRP-3; FRZB1; SFRP3; SRFP3; FRZB-1; FRZB-PEN; FIZ; FRE; FRP; FRZB1; SFRP3; sFRP-3]
uniprot entry name :
SFRP3_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse
sequence length :
325
purity :
Affinity Purification
storage stability :
Store at -20 degree C. Avoid freeze / thaw cycles.
tested application :
Western Blot (WB), Immunofluorescence (IF)
app notes :
WB: 1:500 - 1:2000. IF: 1:10-1:100
image1 heading :
Western Blot (WB)
image2 heading :
Immunofluorescence (IF)
other info1 :
Source: Rabbit. Category: Primary Antibody
other info2 :
Immunogen: Recombinant protein of human FRZB. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
products categories :
Polyclonal
products description :
The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility.
ncbi gi num :
14194748
ncbi acc num :
Q92765.2
uniprot acc num :
Q92765
ncbi mol weight :
Calculated: 36kDa. Observed: 38kDa
ncbi pathways :
Adipogenesis Pathway (198832); Endochondral Ossification Pathway (198812)
ncbi summary :
The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]
uniprot summary :
FRZB: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. Defects in FRZB are associated with susceptibility to osteoarthritis type 1(OS1). Osteoarthritis is a degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement. Belongs to the secreted frizzled-related protein (sFRP) family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 2q32.1. Cellular Component: extracellular space; membrane; integral to membrane. Molecular Function: G-protein coupled receptor activity; Wnt-protein binding; Wnt receptor activity. Biological Process: negative regulation of cell proliferation; convergent extension involved in organogenesis; negative regulation of Wnt receptor signaling pathway; positive regulation of apoptosis; positive regulation of fat cell differentiation; neural crest cell differentiation; negative regulation of cell growth; skeletal development. Disease: Osteoarthritis Susceptibility 1
size1 :
0.05 mL
price1 :
200 USD
size2 :
0.1 mL
price2 :
275
size3 :
0.2 mL
price3 :
430
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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