product summary
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company name :
MyBioSource
product type :
antibody
product name :
TGM3 Polyclonal Antibody
catalog :
MBS9125679
quantity :
0.05 mL
price :
200 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunocytochemistry
more info or order :
image
image 1 :
Western blot analysis of extracts of various cell lines, using TGM3 antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
product information
catalog number :
MBS9125679
products type :
Antibody
products full name :
TGM3 Polyclonal Antibody
products short name :
[TGM3]
products name syn :
[TGE, UHS2]
other names :
[Protein-glutamine gamma-glutamyltransferase E; Protein-glutamine gamma-glutamyltransferase E; protein-glutamine gamma-glutamyltransferase E; TG(E); TGase E; TGase-3; transglutaminase E; transglutaminase-3; E polypeptide, protein-glutamine-gamma-glutamyltransferase; transglutaminase 3; Transglutaminase E; TG(E); TGE; TGase E; Transglutaminase-3; TGase-3]
products gene name :
[TGM3]
other gene names :
[TGM3; TGM3; TGE; TG(E); TGE; TGase E; TGase-3]
uniprot entry name :
TGM3_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse
sequence length :
693
purity :
Affinity Purification
storage stability :
Store at -20°C. Avoid freeze / thaw cycles
tested application :
WB, IF
app notes :
WB: 1:500 - 1:2000. 1: 10-1:100
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: Recombinant Protein. Calculated MW : 76 kDa. Observed MW: 72 kDa
other info2 :
Immunogen: Recombinant protein of human TGM3. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
products categories :
Polyclonal
products description :
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle.
ncbi gi num :
257051080
ncbi acc num :
Q08188.4
uniprot acc num :
Q08188
ncbi summary :
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle. [provided by RefSeq, Jul 2008]
uniprot summary :
TGM3: Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold. In hair follicles, involved in cross- linking structural proteins to hardening the inner root sheath. Belongs to the transglutaminase superfamily. Transglutaminase family. Protein type: EC 2.3.2.13; Membrane protein, peripheral; Transferase. Chromosomal Location of Human Ortholog: 20q11.2. Cellular Component: extrinsic to internal side of plasma membrane; cytoplasm. Molecular Function: protein-glutamine gamma-glutamyltransferase activity; transferase activity, transferring acyl groups; calcium ion binding; catalytic activity. Biological Process: keratinocyte differentiation; cell envelope organization and biogenesis; hair follicle morphogenesis; keratinization; protein modification process; peptide cross-linking; protein tetramerization
size1 :
0.05 mL
price1 :
200 USD
size2 :
0.1 mL
price2 :
275
size3 :
0.2 mL
price3 :
430
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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