product summary
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company name :
MyBioSource
product type :
antibody
product name :
MAP4K3
catalog :
MBS9125307
quantity :
0.05 mL
price :
200 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry
more info or order :
MyBioSource product webpage
image
image 1 :
MyBioSource MBS9125307 image 1
Western blot analysis of extracts of various cell lines, using MAP4K3 antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
image 2 :
MyBioSource MBS9125307 image 2
Immunohistochemistry of paraffin-embedded human liver injury using MAP4K3 antibody at dilution of 1:100 (40x lens).
product information
catalog number :
MBS9125307
products type :
Antibody
products full name :
MAP4K3
products short name :
[MAP4K3]
other names :
[Mitogen-activated protein kinase kinase kinase kinase 3; Mitogen-activated protein kinase kinase kinase kinase 3; mitogen-activated protein kinase kinase kinase kinase 3; MEK kinase kinase 3; MAPK/ERK kinase kinase kinase 3; germinal center kinase-like kinase; germinal center kinase-related protein kinase; mitogen-activated protein kinase kinase kinase kinase 3; Germinal center kinase-related protein kinase; GLK; MAPK/ERK kinase kinase kinase 3; MEK kinase kinase 3; MEKKK 3]
products gene name :
[MAP4K3]
other gene names :
[MAP4K3; MAP4K3; GLK; MEKKK3; MEKKK 3; MAPKKKK3; RAB8IPL1; RAB8IPL1; GLK; MEK kinase kinase 3; MEKKK 3]
uniprot entry name :
M4K3_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
894
purity :
Affinity purification
storage stability :
Store at -20?. Avoid freeze / thaw cycles.
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB 1:500 - 1:2000. IHC 1:50 - 1:200
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Species: Human. Immunogen: Recombinant Protein
other info2 :
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
products categories :
Polyclonal
ncbi gi num :
29427817
ncbi acc num :
Q8IVH8.1
uniprot acc num :
Q8IVH8
ncbi mol weight :
Observed MW: 110kDa. Calculated MW: 98kDa/100kDa/101kDa
ncbi pathways :
Insulin Signaling Pathway (198845); MAPK Signaling Pathway (198779); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); TNF Receptor Signaling Pathway (138053)
ncbi summary :
This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
uniprot summary :
KHS2: an ubiquitous protein kinase of the STE20 family. May play a role in the response to environmental stress. Regulated by amino acids and acts upstream of mTORC1 and JNK. Required for maximal S6K and 4E-BP1 phosphorylation. Interacts with PPP2R5E, a regulatory subunit of PP2A. Following amino acid withdrawal, pS170 is dephosphorylated via PP2A. The dephosphorylation of pS170 by PP2A in response to amino acid restriction inhibits mTORC1 signaling. The inhibition of PPP2R5E expression prevents the dephosphorylation of KHS2 pS170, impairing mTORC1 inhibition during amino acid withdrawal. Three alternatively spliced isoforms have been described. Protein type: Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; STE group; STE20 family; KHS subfamily. Chromosomal Location of Human Ortholog: 2p22.1. Cellular Component: cytoplasm. Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity. Biological Process: regulation of catalytic activity; JNK cascade; protein amino acid phosphorylation; response to UV
size1 :
0.05 mL
price1 :
200 USD
size2 :
0.1 mL
price2 :
275
size3 :
0.2 mL
price3 :
430
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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