LILRB4 | MyBioSource MBS9125297 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

LILRB4

catalog :

MBS9125297

quantity :

0.05 mL

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of extracts of various cell lines, using LILRB4 antibody (MBS9125297) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

product information

catalog number :

MBS9125297

products type :

Antibody

products full name :

LILRB4

products short name :

[LILRB4]

products name syn :

[LILRB4; CD85K; ILT-3; ILT3; LIR-5; LIR5; leukocyte immunoglobulin like receptor B4]

other names :

[Leukocyte immunoglobulin-like receptor subfamily B member 4; Leukocyte immunoglobulin-like receptor subfamily B member 4; leukocyte immunoglobulin-like receptor subfamily B member 4; immunoglobulin-like transcript 3; CD85 antigen-like family member K; monocyte inhibitory receptor HM18; leukocyte immunoglobulin-like receptor 5; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4; CD85 antigen-like family member K; Immunoglobulin-like transcript 3; ILT-3; Leukocyte immunoglobulin-like receptor 5; LIR-5; Monocyte inhibitory receptor HM18; CD_antigen: CD85k]

products gene name :

[LILRB4]

other gene names :

[LILRB4; LILRB4; ILT3; LIR5; CD85K; ILT-3; LIR-5; ILT3; LIR5; ILT-3; LIR-5]

uniprot entry name :

LIRB4_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

448

purity :

Affinity purification

form :

PBS with 0.02% sodium azide, 50% glycerol, pH7.3

storage stability :

Store at -20°C. Avoid freeze / thaw cycles

tested application :

Western Blot (WB)

app notes :

Recommended dilution: WB: 1:500-1:2000

image1 heading :

Western Blot (WB)

other info1 :

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 22-259 of human LILRB4 (NP_001265355.2).

products categories :

Polyclonal

products description :

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen- presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

ncbi gi num :

322510117

ncbi acc num :

Q8NHJ6.3

uniprot acc num :

Q8NHJ6

ncbi mol weight :

Calculated: 49 kDa. Observed: 45-49kDa

ncbi pathways :

Adaptive Immune System Pathway (366160); Immune System Pathway (106386); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (106413); Osteoclast Differentiation Pathway (193147); Osteoclast Differentiation Pathway (193096)

ncbi summary :

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

LILRB4: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5- signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, misc.; Membrane protein, integral. Chromosomal Location of Human Ortholog: 19q13.4. Cellular Component: integral to membrane; plasma membrane. Molecular Function: protein binding; receptor activity; antigen binding. Biological Process: negative regulation of osteoclast differentiation; immune system process; signal transduction

size1 :

0.05 mL

price1 :

200 USD

size2 :

0.1 mL

price2 :

275

size3 :

0.2 mL

price3 :

430

more info or order :

MyBioSource product webpage