Rat Alpha-1-antitrypsin, SERPINA1 ELISA Kit | MyBioSource MBS910027 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Rat Alpha-1-antitrypsin, SERPINA1 ELISA Kit

catalog :

MBS910027

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS910027

products type :

ELISA Kit

products full name :

Rat Alpha-1-antitrypsin, SERPINA1 ELISA Kit

products short name :

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin) , member 1

products name syn :

Rat Alpha-1-antitrypsin (SERPINA1) ELISA kit; A1A; A1AT; AAT; MGC23330; MGC9222; PI; PI1; PRO2275; OTTHUMP00000197150; protease inhibitor 1 (anti-elastase); alpha-1-antitrypsin; serine (or cysteine) proteinase inhibitor; clade A; member 1; serine; serpin peptidase inhibitor; clade A (alpha-1 antiproteinase; antitrypsin); member 1

other names :

alpha-1-antiproteinase; Alpha-1-antiproteinase; alpha-1-antiproteinase; serpin A1; alpha-1-protease inhibitor; alpha-1-proteinase inhibitor; serine protease inhibitor alpha 1; alpha-1-antitrypsin (protease inhibitor); serine (or cysteine) proteinase inhibitor, clade A, member 1; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; Alpha-1-antitrypsin; Alpha-1-proteinase inhibitor; Serpin A1

products gene name :

SERPINA1

other gene names :

Serpina1; Serpina1; Pi; AAT; Spi1

uniprot entry name :

A1AT_RAT

reactivity :

Rat

sequence length :

411

specificity :

This assay has high sensitivity and excellent specificity for detection of rat SERPINA1. No significant cross-reactivity or interference between rat SERPINA1 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, tissue homogenates. Assay Type: Competitive. Detection Range: 62.5 ng/ml-4000 ng/ml. Sensitivity: Typically less than 15.6 ng/ml

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

products description :

Principle of the Assay: This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with SERPINA1. Standards or samples are added to the appropriate microtiter plate wells with Horseradish Peroxidase (HRP) conjugated antibody preparation specific for SERPINA1. The competitive inhibition reaction is launched between with pre-coated SERPINA1 and SERPINA1 in samples. A substrate solution is added to the wells and the color develops in opposite to the amount of SERPINA1 in the samples. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

51036655

ncbi acc num :

NP_071964.2

ncbi gb acc num :

NM_022519.2

uniprot acc num :

P17475

ncbi mol weight :

46,136 Da

ncbi pathways :

Complement And Coagulation Cascades Pathway (198461); Complement And Coagulation Cascades Pathway (83465); Complement And Coagulation Cascades Pathway (484)

uniprot summary :

SERPINA1: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD). A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Inhibitor; Secreted; Secreted, signal peptide. Cellular Component: Golgi apparatus; extracellular space; endoplasmic reticulum. Molecular Function: serine-type endopeptidase inhibitor activity; identical protein binding; protein binding; protease binding; endopeptidase inhibitor activity; glycoprotein binding. Biological Process: response to chromate; response to inorganic substance; response to triglyceride; response to cytokine stimulus; response to lead ion; acute-phase response; response to methanol; response to hypoxia; response to lipopolysaccharide; inflammatory response; response to organic cyclic substance; response to estradiol stimulus

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage