Human Integrin alpha-2, ITGA2 ELISA Kit | MyBioSource MBS909817 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Integrin alpha-2, ITGA2 ELISA Kit

catalog :

MBS909817

quantity :

24-Strip-Wells (LIMIT 1)

price :

240 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS909817

products type :

ELISA Kit

products full name :

Human Integrin alpha-2, ITGA2 ELISA Kit

products short name :

[integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)]

products name syn :

[Human Integrin alpha-2 (ITGA2) ELISA kit; BR; CD49B; GPIa; VLA-2; VLAA2; integrin alpha 2; platelet antigen Br; platelet glycoprotein GPIa; platelet glycoprotein Ia; very late activation protein 2 receptor; alpha-2 subunit; integrin; alpha 2 (CD49B; alpha 2 subunit of VLA-2 receptor)]

other names :

[integrin alpha-2; Integrin alpha-2; integrin alpha-2; collagen receptor; platelet antigen Br; platelet glycoprotein GPIa; VLA2 receptor, alpha-2 subunit; CD49 antigen-like family member B; platelet membrane glycoprotein Ia; human platelet alloantigen system 5; very late activation protein 2 receptor, alpha-2 subunit; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA-2 subunit alpha; CD_antigen: CD49b]

products gene name :

[ITGA2]

other gene names :

[ITGA2; ITGA2; BR; GPIa; CD49B; HPA-5; VLA-2; VLAA2; CD49B; GPIa]

uniprot entry name :

ITA2_HUMAN

reactivity :

Human

sequence length :

1181

specificity :

This assay has high sensitivity and excellent specificity for detection of human ITGA1. No significant cross-reactivity or interference between human ITGA1 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma, Tissue Homogenates. Assay Type: Quantitative Sandwich. Detection Range: 0.312 ng/ml-20 ng/ml. Sensitivity: 0.078 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

products description :

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for ITGA1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any ITGA1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for ITGA1 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of ITGA1 bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

116295258

ncbi acc num :

NP_002194.2

ncbi gb acc num :

NM_002203.3

uniprot acc num :

P17301

ncbi mol weight :

129,295 Da

ncbi pathways :

Arf6 Trafficking Events Pathway (137954); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Axon Guidance Pathway (105688); CHL1 Interactions Pathway (161007); CXCR4-mediated Signaling Events Pathway (137910); Developmental Biology Pathway (477129); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); ECM-receptor Interaction Pathway (83068)

ncbi summary :

This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

uniprot summary :

ITGA2: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Belongs to the integrin alpha chain family. Protein type: Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis; Cell adhesion. Chromosomal Location of Human Ortholog: 5q11.2. Cellular Component: focal adhesion; cell surface; perinuclear region of cytoplasm; plasma membrane; nerve terminal; integrin complex; nucleus; external side of plasma membrane. Molecular Function: collagen binding; integrin binding; viral receptor activity; protein binding; protein heterodimerization activity; metal ion binding; laminin binding. Biological Process: axon guidance; extracellular matrix organization and biogenesis; response to muscle activity; entry of virus into host cell; positive regulation of cell adhesion; positive regulation of positive chemotaxis; positive regulation of translation; positive regulation of leukocyte migration; cell-matrix adhesion; positive regulation of smooth muscle cell proliferation; positive regulation of collagen biosynthetic process; positive regulation of collagen binding; positive regulation of cell projection organization and biogenesis; mesodermal cell differentiation; positive regulation of smooth muscle cell migration; response to organic cyclic substance; response to L-ascorbic acid; establishment of protein localization; mammary gland development; positive regulation of smooth muscle contraction; cell adhesion; positive regulation of DNA binding; substrate-bound cell migration; integrin-mediated signaling pathway; response to drug; skin morphogenesis; hypotonic response; cell-substrate adhesion; cellular response to hormone stimulus; cell proliferation; detection of mechanical stimulus involved in sensory perception of pain; organ morphogenesis; response to hypoxia; cell adhesion mediated by integrin; blood coagulation; positive regulation of phagocytosis, engulfment; positive regulation of inflammatory response; response to amine stimulus; positive regulation of transmission of nerve impulse. Disease: Bleeding Disorder, Platelet-type, 9

size1 :

24-Strip-Wells (LIMIT 1)

price1 :

240 USD

size2 :

48-Strip-Wells

price2 :

495

size3 :

96-Strip-Wells

price3 :

710

size4 :

5x96-Strip-Wells

price4 :

2705

size5 :

10x96-Strip-Wells

price5 :

5145

more info or order :

MyBioSource product webpage