Mouse Macrophage scavenger receptor types I and II, MSR1 ELISA Kit | MyBioSource MBS908362 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse Macrophage scavenger receptor types I and II, MSR1 ELISA Kit

catalog :

MBS908362

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS908362

products type :

ELISA Kit

products full name :

Mouse Macrophage scavenger receptor types I and II, MSR1 ELISA Kit

products short name :

macrophage scavenger receptor 1

products name syn :

Mouse Macrophage scavenger receptor types I and II (MSR1) ELISA kit; CD204; SCARA1; SR-A; phSR1; phSR2; OTTHUMP00000120049; macrophage acetylated LDL receptor I and II; macrophage scavenger receptor type III; scavenger receptor class A; member 1; macrophage scavenger receptor 1

other names :

macrophage scavenger receptor types I and II isoform b; Macrophage scavenger receptor types I and II; macrophage scavenger receptor types I and II; SR-A; scavenger receptor type A; macrophage acetylated LDL receptor I and II; macrophage scavenger receptor 1; Macrophage acetylated LDL receptor I and II; Scavenger receptor type A; SR-A; CD_antigen: CD204

products gene name :

MSR1

other gene names :

Msr1; Msr1; MSR; Scvr; MRS-A; MSR-A; SR-AI; SR-AII; Scara1; Scvr; SR-A

uniprot entry name :

MSRE_MOUSE

reactivity :

Mouse

sequence length :

458

specificity :

This assay has high sensitivity and excellent specificity for detection of Mouse MSR1. No significant cross-reactivity or interference between Mouse MSR1 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, tissue homogenates. Assay Type: Sandwich. Detection Range: 0.156 ng/ml-10 ng/ml. Sensitivity: 0.039 ng/ml

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Detection Wavelength: 450 nm. Sample Volume: 50-100ul. Protein Biological Process 1: Immunity. Protein Biological Process 3: Endocytosis

products description :

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for MSR1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any MSR1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for MSR1 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of MSR1 bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

164664520

ncbi acc num :

NP_001106797.1

ncbi gb acc num :

NM_001113326.1

uniprot acc num :

P30204

ncbi mol weight :

50,170 Da

ncbi pathways :

Phagosome Pathway (153914); Phagosome Pathway (153859)

uniprot summary :

MSR1: Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize actetylated LDL. Defects in MSR1 may be a cause of prostate cancer (PC). A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet- ring cell carcinoma and neuroendocrine carcinoma. MSR1 variants may play a role in susceptibility to prostate cancer. MSR1 variants have been found in individuals with prostate cancer and co-segregate with the disease in some families. Defects in MSR1 may be a cause of Barrett esophagus (BE). A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Genetic variants in MSR1 have been found in individuals with Barrett esophagus and are thought to contribute to disease susceptibility. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Cellular Component: collagen; membrane; plasma membrane; integral to membrane; cytoplasmic vesicle; cytosol. Molecular Function: low-density lipoprotein binding; scavenger receptor activity. Biological Process: receptor-mediated endocytosis; cholesterol transport; lipoprotein transport; endocytosis

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage