Mouse Vitamin K-dependent protein S, PROS1 ELISA Kit | MyBioSource MBS906634 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse Vitamin K-dependent protein S, PROS1 ELISA Kit

catalog :

MBS906634

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

citations: 1

Reference
Ubil E, Caskey L, Holtzhausen A, Hunter D, Story C, Earp H. Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response. J Clin Invest. 2018;128:2356-2369 pubmed publisher

product information

catalog number :

MBS906634

products type :

ELISA Kit

products full name :

Mouse Vitamin K-dependent protein S, PROS1 ELISA Kit

products short name :

protein S (alpha)

products name syn :

Mouse Vitamin K-dependent protein S (PROS1) ELISA kit; PROS; PS21; PS22; PS23; PS24; PS25; PSA; protein S; alpha; protein Sa; vitamin K-dependent plasma protein S; protein S (alpha)

other names :

vitamin K-dependent protein S; Vitamin K-dependent protein S; vitamin K-dependent protein S; protein S (alpha)

products gene name :

PROS1

other gene names :

Pros1; Pros1; AW214361; Pros

uniprot entry name :

PROS_MOUSE

reactivity :

Mouse

sequence length :

675

specificity :

This assay has high sensitivity and excellent specificity for detection of mouse PROS1. No significant cross-reactivity or interference between mouse PROS1 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, tissue homogenates. Assay Type: Quantitative Competitive. Sensitivity: Typically less than 1.56 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

products description :

Principle of the Assay: This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with PROS1. Standards or samples are added to the appropriate microtiter plate wells with Horseradish Peroxidase (HRP) conjugated antibody preparation specific for PROS1. The competitive inhibition reaction is launched between with pre-coated PROS1 and PROS1 in samples. A substrate solution is added to the wells and the color develops in opposite to the amount of PROS1 in the samples. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

46309455

ncbi acc num :

NP_035303.1

ncbi gb acc num :

NM_011173.2

uniprot acc num :

Q08761

ncbi mol weight :

74,934 Da

ncbi pathways :

Cell Surface Interactions At The Vascular Wall Pathway (575507); Common Pathway (575505); Complement And Coagulation Cascades Pathway (198335); Complement And Coagulation Cascades Pathway (83270); Complement And Coagulation Cascades Pathway (484); Formation Of Fibrin Clot (Clotting Cascade) Pathway (575502); Gamma-carboxylation Of Protein Precursors Pathway (575197); Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway (575196); Hemostasis Pathway (575479); Metabolism Of Proteins Pathway (575185)

uniprot summary :

PROS1: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. Defects in PROS1 are the cause of thrombophilia due to protein S deficiency, autosomal dominant (THPH5). A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Based on the plasma levels of total and free PROS1 antigen as well as the serine protease-activated protein C cofactor activity, three types of PROS1D have been described: type I, characterized by reduced total and free PROS1 antigen levels together with reduced anticoagulant activity; type III, in which only free PROS1 antigen and PROS1 activity levels are reduced; and the rare type II which is characterized by normal concentrations of both total and free PROS1 antigen, but low cofactor activity. Defects in PROS1 are the cause of thrombophilia due to protein S deficiency, autosomal recessive (THPH6). A very rare and severe hematologic disorder resulting in thrombosis and secondary hemorrhage usually beginning in early infancy. Some affected individuals develop neonatal purpura fulminans, multifocal thrombosis, or intracranial hemorrhage. Protein type: Secreted; Secreted, signal peptide. Cellular Component: extracellular space; protein complex; extracellular region. Molecular Function: protein complex binding; calcium ion binding. Biological Process: fibrinolysis; hemostasis; positive regulation of phagocytosis; negative regulation of coagulation; blood coagulation

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage