Human Growth arrest-specific protein 6, GAS6 ELISA Kit | MyBioSource MBS906622 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Growth arrest-specific protein 6, GAS6 ELISA Kit

catalog :

MBS906622

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS906622

products type :

ELISA Kit

products full name :

Human Growth arrest-specific protein 6, GAS6 ELISA Kit

products short name :

growth arrest-specific 6

products name syn :

Human Growth arrest-specific protein 6 (GAS6) ELISA kit; AXLLG; AXSF; DKFZp666G247; FLJ34709; AXL receptor tyrosine kinase ligand; AXL stimulatory factor; growth arrest-specific 6

other names :

growth arrest-specific protein 6; Growth arrest-specific protein 6; growth arrest-specific protein 6; AXL stimulatory factor; AXL receptor tyrosine kinase ligand; growth arrest-specific 6; AXL receptor tyrosine kinase ligand

products gene name :

GAS6

other gene names :

GAS6; GAS6; AXSF; AXLLG; AXLLG; GAS-6

uniprot entry name :

GAS6_HUMAN

reactivity :

Human

sequence length :

678

specificity :

This assay has high sensitivity and excellent specificity for detection of Human GAS6. No significant cross-reactivity or interference between Human GAS6 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, tissue homogenates. Assay Type: Competitive. Detection Range: 3.12 pg/ml-200 pg/ml. Sensitivity: 1.56 pg/ml

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Detection Wavelength: 450 nm. Sample Volume: 50-100ul

products description :

Principle of the Assay: This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with GAS6. Standards or samples are added to the appropriate microtiter plate wells with Horseradish Peroxidase (HRP) conjugated antibody preparation specific for GAS6. The competitive inhibition reaction is launched between with pre-coated GAS6 and GAS6 in samples. A substrate solution is added to the wells and the color develops in opposite to the amount of GAS6 in the sample. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

4557617

ncbi acc num :

NP_000811.1

ncbi gb acc num :

NM_000820.3

uniprot acc num :

Q14393

ncbi mol weight :

79,677 Da

ncbi pathways :

Cell Surface Interactions At The Vascular Wall Pathway (106062); Gamma-carboxylation Of Protein Precursors Pathway (106233); Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway (106232); Hemostasis Pathway (106028); Metabolism Of Proteins Pathway (106230); PTM: Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway (106231); Platelet Activation, Signaling And Aggregation Pathway (106034); Platelet Degranulation Pathway (106050); Post-translational Protein Modification Pathway (161012); Removal Of Aminoterminal Propeptides From Gamma-carboxylated Proteins Pathway (106235)

ncbi summary :

This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]

uniprot summary :

GAS6: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Ligand, receptor tyrosine kinase; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 13q34. Cellular Component: extracellular space; Golgi lumen; endoplasmic reticulum lumen; cytoplasm; extracellular region. Molecular Function: voltage-gated calcium channel activity; protein binding; phosphatidylserine binding; caspase inhibitor activity; protein tyrosine kinase activator activity; calcium ion binding; receptor tyrosine kinase binding; receptor agonist activity; molecular adaptor activity; receptor binding. Biological Process: proteolysis; enzyme linked receptor protein signaling pathway; protein amino acid phosphorylation; positive regulation of fibroblast proliferation; viral envelope fusion with host membrane; negative regulation of protein import into nucleus, translocation; regulation of growth; positive regulation of phagocytosis; negative regulation of interleukin-6 production; cell cycle arrest; cell adhesion; positive regulation of TOR signaling pathway; platelet activation; organ regeneration; activation of protein kinase B; negative regulation of transcription factor activity; cellular response to starvation; peptidyl-glutamic acid carboxylation; negative regulation of transcription, DNA-dependent; leukocyte migration; negative regulation of interleukin-1 secretion; negative regulation of apoptosis; entry of virus into host cell; neuron migration; negative regulation of caspase activity; signal transduction; positive regulation of protein export from nucleus; positive regulation of natural killer cell differentiation; platelet degranulation; positive regulation of glomerular filtration; negative regulation of interferon-gamma production; protein kinase B signaling cascade; virion attachment, binding of host cell surface receptor; cell migration; viral genome replication; negative regulation of tumor necrosis factor production; post-translational protein modification; positive regulation of peptidyl-serine phosphorylation; phagocytosis; cell-substrate adhesion; cell proliferation; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; cellular protein metabolic process; positive regulation of protein kinase activity; positive regulation of protein amino acid phosphorylation; blood coagulation; positive regulation of cytokine and chemokine mediated signaling pathway; apoptotic cell clearance

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage