Human Fermitin family homolog 3, FERMT3 ELISA Kit | MyBioSource MBS906327 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Fermitin family homolog 3, FERMT3 ELISA Kit

catalog :

MBS906327

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS906327

products type :

ELISA Kit

products full name :

Human Fermitin family homolog 3, FERMT3 ELISA Kit

products short name :

fermitin family homolog 3 (Drosophila)

products name syn :

Human Fermitin family homolog 3 (FERMT3) ELISA kit; KIND3; MGC10966; MIG-2; MIG2B; UNC112C; URP2; URP2SF; UNC-112 related protein 2; fermitin family homolog 3; kindlin 3; kindlin-3; fermitin family homolog 3 (Drosophila)

other names :

fermitin family homolog 3 short form; Fermitin family homolog 3; fermitin family homolog 3; kindlin 3; MIG2-like protein; UNC-112 related protein 2; unc-112-related protein 2; fermitin family member 3; Kindlin-3; MIG2-like protein; Unc-112-related protein 2

products gene name :

FERMT3

other gene names :

FERMT3; FERMT3; URP2; KIND3; MIG-2; MIG2B; URP2SF; UNC112C; KIND3; MIG2B; URP2

uniprot entry name :

URP2_HUMAN

reactivity :

Human

sequence length :

663

specificity :

This assay has high sensitivity and excellent specificity for detection of Human FERMT3. No significant cross-reactivity or interference between Human FERMT3 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, tissue homogenates, Cell lysates. Assay Type: Sandwich. Detection Range: 0.156 ng/ml-10 ng/ml. Sensitivity: 0.039 ng/ml

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Detection Wavelength: 450 nm. Sample Volume: 50-100ul. Protein Biological Process 1: Cell Adhesion. Protein Biological Process 3: Cell adhesion

products description :

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for FERMT3 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any FERMT3 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for FERMT3 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of FERMT3 bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

28626504

ncbi acc num :

NP_113659.3

ncbi gb acc num :

NM_031471.5

uniprot acc num :

Q86UX7

ncbi mol weight :

75,953 Da

ncbi summary :

Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2010]

uniprot summary :

kindlin-3: Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs). Defects in FERMT3 are the cause of leukocyte adhesion deficiency type 3 (LAD3); also called leukocyte adhesion deficiency 1 variant (LAD1v). LAD3 is a rare syndrome characterized by infections without pus formation in the presence of a leukocytosis combined with a Glanzmann-type bleeding disorder, resulting from a hematopoietic defect in integrin activation. Symptoms arise from an inability to activate the integrins expressed on hematopoietic cells, including platelets and leukocytes. Belongs to the kindlin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell adhesion. Chromosomal Location of Human Ortholog: 11q13.1. Cellular Component: cell projection; membrane; podosome; cell junction. Molecular Function: integrin binding. Biological Process: integrin activation; integrin-mediated signaling pathway; leukocyte adhesion; regulation of cell-cell adhesion mediated by integrin. Disease: Leukocyte Adhesion Deficiency, Type Iii

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage