catalog number :
MBS904451
products type :
ELISA Kit
products full name :
Human Multimerin-2, MMRN2 ELISA Kit
products short name :
multimerin 2
products name syn :
Human Multimerin-2 (MMRN2) ELISA kit; EMILIN3; EndoGlyx-1; FLJ13465; EMILIN-like protein EndoGlyx-1; elastin microfibril interfacer 3; multimerin 2
other names :
multimerin-2; Multimerin-2; multimerin-2; endoGlyx-1 p125/p140 subunit; EMILIN-like protein EndoGlyx-1; elastin microfibril interfacer 3; elastin microfibril interface located protein 3; multimerin 2; EMILIN-3; Elastin microfibril interface located protein 3; Elastin microfibril interfacer 3; EndoGlyx-1 p125/p140 subunit
products gene name :
MMRN2
other gene names :
MMRN2; MMRN2; EMILIN3; EMILIN-3; ENDOGLYX-1; EMILIN3; Elastin microfibril interfacer 3
uniprot entry name :
MMRN2_HUMAN
specificity :
This assay has high sensitivity and excellent specificity for detection of Human MMRN2. No significant cross-reactivity or interference between Human MMRN2 and analogues was observed.
storage stability :
Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
other info1 :
Samples: Serum, plasma, tissue homogenates. Assay Type: Sandwich. Detection Range: 0.156 ng/ml-10 ng/ml. Sensitivity: 0.039 ng/ml
other info2 :
Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Detection Wavelength: 450 nm. Sample Volume: 50-100ul
products description :
Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for MMRN2 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any MMRN2 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for MMRN2 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of MMRN2 bound in the initial step. The color development is stopped and the intensity of the color is measured.
ncbi acc num :
NP_079032.2
ncbi gb acc num :
NM_024756.2
ncbi mol weight :
104,409 Da
ncbi summary :
This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6. [provided by RefSeq, Aug 2012]
uniprot summary :
MMRN2: Heteromer of p110, p125, p140 and p200 subunits; disulfide-linked. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 10q23.2. Cellular Component: extracellular space; basement membrane. Molecular Function: protein binding. Biological Process: negative regulation of vascular endothelial growth factor receptor signaling pathway; angiogenesis
size4 :
10x96-Strip-Wells