Human epiregulin, EREG ELISA Kit | MyBioSource MBS904261 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human epiregulin, EREG ELISA Kit

catalog :

MBS904261

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS904261

products type :

ELISA Kit

products full name :

Human epiregulin, EREG ELISA Kit

products short name :

epiregulin

products name syn :

Human epiregulin (EREG) ELISA kit; ER; ; epiregulin

other names :

proepiregulin preproprotein; Proepiregulin; proepiregulin; epiregulin

products gene name :

EREG

other gene names :

EREG; EREG; ER; EPR

uniprot entry name :

EREG_HUMAN

reactivity :

Human

sequence length :

169

specificity :

This assay has high sensitivity and excellent specificity for detection of human EREG. No significant cross-reactivity or interference between human EREG and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, cell culture supernates, tissue homogenates. Assay Type: Sandwich. Detection Range: 15.6 pg/ml-1000 pg/ml. Sensitivity: 3.9 pg/ml.

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

products description :

Principle of the Assay This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for EREG has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any EREG present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for EREG is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of EREG bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

4557567

ncbi acc num :

NP_001423.1

ncbi gb acc num :

NM_001432.2

uniprot acc num :

O14944

ncbi mol weight :

19,044 Da

ncbi pathways :

ErbB Receptor Signaling Network Pathway (138016); ErbB Signaling Pathway (198844); ErbB Signaling Pathway (83049); ErbB Signaling Pathway (458); ErbB4 Signaling Events Pathway (137991); GRB2 Events In ERBB2 Signaling Pathway (530736); Nuclear Signaling By ERBB4 Pathway (530744); PI3K Events In ERBB2 Signaling Pathway (530737); PI3K Events In ERBB4 Signaling Pathway (530743); SHC1 Events In ERBB2 Signaling Pathway (530735)

ncbi summary :

Epiregulin is a member of the epidermal growth factor family. Epiregulin can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. [provided by RefSeq, Jul 2008]

uniprot summary :

Epiregulin: Ligand of the EGF receptor/EGFR and ERBB4. May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 4q13.3. Cellular Component: extracellular space; integral to plasma membrane; extracellular region. Molecular Function: protein binding; growth factor activity; epidermal growth factor receptor binding. Biological Process: response to peptide hormone stimulus; nerve growth factor receptor signaling pathway; wound healing; activation of MAPK activity; positive regulation of interleukin-6 biosynthetic process; positive regulation of smooth muscle cell proliferation; female meiosis; negative regulation of smooth muscle cell differentiation; negative regulation of cell proliferation; primary follicle stage, oogenesis; positive regulation of fibroblast proliferation; positive regulation of epidermal growth factor receptor activity; cell-cell signaling; positive regulation of innate immune response; positive regulation of cell proliferation; ovarian cumulus expansion; angiogenesis; negative regulation of epithelial cell proliferation; positive regulation of cytokine production; epidermal growth factor receptor signaling pathway; anatomical structure morphogenesis; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of mitosis; cytokine and chemokine mediated signaling pathway; positive regulation of cytokine biosynthetic process; keratinocyte proliferation; luteinizing hormone signaling pathway; oocyte maturation; keratinocyte differentiation; ovulation; organ morphogenesis; positive regulation of protein kinase activity; mRNA transcription; innate immune response; negative regulation of transcription, DNA-dependent; positive regulation of DNA replication; positive regulation of phosphorylation

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage