catalog number :
MBS902961
products type :
ELISA Kit
products full name :
Human Twisted gastrulation protein homolog 1, TWSG1 ELISA Kit
products short name :
twisted gastrulation homolog 1 (Drosophila)
products name syn :
Human Twisted gastrulation protein homolog 1 (TWSG1) ELISA kit; TSG; twisted gastrulation; twisted gastrulation homolog 1 (Drosophila)
other names :
twisted gastrulation protein homolog 1; Twisted gastrulation protein homolog 1; twisted gastrulation protein homolog 1; twisted gastrulation homolog 1; twisted gastrulation BMP signaling modulator 1
products gene name :
TWSG1
other gene names :
TWSG1; TWSG1; TSG; TSG; PSEC0250
uniprot entry name :
TWSG1_HUMAN
specificity :
This assay has high sensitivity and excellent specificity for detection of Human TWSG1. No significant cross-reactivity or interference between Human TWSG1 and analogues was observed.
storage stability :
Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
other info1 :
Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Sample Type: serum, plasma, tissue homogenates. Detection Range: 125 pg/ml-8000 pg/ml. Detection Wavelength: 450 nm. Sensitivity: 31.25 pg/ml
other info2 :
Sample Volume: 50-100ul
products description :
Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for TWSG1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any TWSG1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for TWSG1 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of TWSG1 bound in the initial step. The color development is stopped and the intensity of the color is measured.
ncbi acc num :
NP_065699.1
ncbi gb acc num :
NM_020648.5
ncbi mol weight :
25,017 Da
uniprot summary :
Function: May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development