Human Plasma protease C1 inhibitor, SERPING1 ELISA Kit | MyBioSource MBS901594 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Plasma protease C1 inhibitor, SERPING1 ELISA Kit

catalog :

MBS901594

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS901594

products type :

ELISA Kit

products full name :

Human Plasma protease C1 inhibitor, SERPING1 ELISA Kit

products short name :

serpin peptidase inhibitor, clade G (C1 inhibitor) , member 1

products name syn :

Human Plasma protease C1 inhibitor (SERPING1) ELISA kit; C1IN; C1INH; C1NH; HAE1; HAE2; complement component 1 inhibitor; plasma protease C1 inhibitor; serine/cysteine proteinase inhibitor clade G member 1; serpin peptidase inhibitor; clade G; member 1; serpin peptidase inhibitor; clade G (C1 inhibitor); member 1

other names :

plasma protease C1 inhibitor; Plasma protease C1 inhibitor; plasma protease C1 inhibitor; serpin G1; C1-inhibiting factor; C1 esterase inhibitor; complement component 1 inhibitor; serine/cysteine proteinase inhibitor clade G member 1; serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; C1 esterase inhibitor; C1-inhibiting factor; Serpin G1

products gene name :

SERPING1

other gene names :

SERPING1; SERPING1; C1IN; C1NH; HAE1; HAE2; C1INH; C1IN; C1NH; C1 Inh; C1Inh

uniprot entry name :

IC1_HUMAN

reactivity :

Human

sequence length :

500

specificity :

This assay has high sensitivity and excellent specificity for detection of human SERPING1. No significant cross-reactivity or interference between human SERPING1 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, tissue homogenates. Assay Type: Quantitative Competitive. Sensitivity: Typically less than 4.7 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

products description :

Principle of the Assay: This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with SERPING1. Standards or samples are added to the appropriate microtiter plate wells with Horseradish Peroxidase (HRP) conjugated antibody preparation specific for SERPING1. The competitive inhibition reaction is launched between with pre-coated SERPING1 and SERPING1 in samples. A substrate solution is added to the wells and the color develops in opposite to the amount of SERPING1 in the samples. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

73858568

ncbi acc num :

NP_000053.2

ncbi gb acc num :

NM_000062.2

uniprot acc num :

P05155

ncbi mol weight :

55,154 Da

ncbi pathways :

Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); Hemostasis Pathway (106028); Intrinsic Pathway (106059); Pertussis Pathway (218111); Pertussis Pathway (218099); Platelet Activation, Signaling And Aggregation Pathway (106034); Platelet Degranulation Pathway (106050)

ncbi summary :

This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]

uniprot summary :

SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 11q12.1. Cellular Component: extracellular space; extracellular region. Molecular Function: serine-type endopeptidase inhibitor activity; protein binding. Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; fibrinolysis; platelet degranulation; blood circulation; innate immune response; blood coagulation; blood coagulation, intrinsic pathway; complement activation, classical pathway; aging. Disease: Angioedema, Hereditary, Type I; Complement Component 4, Partial Deficiency Of

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage