Human Amyloid beta A4 precursor protein-binding family A member 2, APBA2 ELISA Kit | MyBioSource MBS900759 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Amyloid beta A4 precursor protein-binding family A member 2, APBA2 ELISA Kit

catalog :

MBS900759

quantity :

48-Strip-Wells

price :

510 USD

product information

catalog number :

MBS900759

products type :

ELISA Kit

products full name :

Human Amyloid beta A4 precursor protein-binding family A member 2, APBA2 ELISA Kit

products short name :

amyloid beta (A4) precursor protein-binding, family A, member 2

products name syn :

Human Amyloid beta A4 precursor protein-binding family A member 2 (APBA2) ELISA kit; D15S1518E; HsT16821; LIN-10; MGC99508; MGC:14091; MINT2; X11L; X11-like protein; adapter protein X11beta; amyloid beta (A4) precursor protein-binding; family A; member 2 (X11-like) ; amyloid beta A4 pre; amyloid beta (A4) precursor protein-binding; family A; member 2

other names :

amyloid beta A4 protein-binding family A member 2 isoform b; Amyloid beta A4 precursor protein-binding family A member 2; amyloid beta A4 precursor protein-binding family A member 2; mint-2; X11-like protein; adapter protein X11beta; neuron-specific X11L protein; neuronal munc18-1-interacting protein 2; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like); amyloid beta (A4) precursor protein-binding, family A, member 2; Adapter protein X11beta; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2; Mint-2

products gene name :

APBA2

other gene names :

APBA2; APBA2; X11L; MINT2; LIN-10; HsT16821; X11-BETA; D15S1518E; MGC:14091; MINT2; X11L; Mint-2

uniprot entry name :

APBA2_HUMAN

reactivity :

Human

sequence length :

737

specificity :

This assay has high sensitivity and excellent specificity for detection of Human APBA2. No significant cross-reactivity or interference between Human APBA2 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, tissue homogenates. Assay Type: Sandwich. Detection Range: 37.5 pg/ml-2400 pg/ml. Sensitivity: 9.37 pg/ml

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Detection Wavelength: 450 nm. Sample Volume: 50-100ul. Protein Biological Process 1: Transport. Protein Biological Process 3: Protein transport

products description :

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for APBA2 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any APBA2 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for APBA2 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of APBA2 bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

194353992

ncbi acc num :

NP_001123886.1

ncbi gb acc num :

NM_001130414.1

uniprot acc num :

Q99767

ncbi mol weight :

82,512 Da

ncbi summary :

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

APBA2: Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. Part of a multimeric complex containing STXBP1 and syntaxin-1. Binds to the cytoplasmic domain of amyloid protein beta, and to the nuclear factor NF-kappa-B/p65 via its PDZ domain. Interacts with the N-terminal domain of APBA2BP. Brain. Protein type: Adaptor/scaffold. Chromosomal Location of Human Ortholog: 15q11-q12. Cellular Component: plasma membrane. Molecular Function: protein binding; beta-amyloid binding. Biological Process: nervous system development; synaptic transmission; protein transport; regulation of gene expression; in utero embryonic development; multicellular organism growth; locomotory behavior

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800