catalog number :
MBS859654
products full name :
CD88/C5aR (Ab-338) Antibody
products short name :
[CD88/C5aR]
products name syn :
[C5AR; C5AR1; C5R1; C5a anaphylatoxin chemotactic receptor; C5a-R; CD88 antigen]
other names :
[C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin chemotactic receptor 1; complement C5a receptor 1; C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR; CD_antigen: CD88]
products gene name :
[CD88/C5aR]
other gene names :
[C5AR1; C5AR1; C5A; C5AR; C5R1; CD88; C5AR; C5R1; C5a-R; C5aR]
reactivity :
Human, Mouse
specificity :
CD88/C5aR (Ab-338) antibody detects endogenous levels of total CD88/C5aR protein.
purity :
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at-20 degree C for 1 year.
tested application :
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
app notes :
WB: 1:500~1:1000. IHC: 1:50~1:100. IF: 1:100~1:500. ELISA: 1:5000
image1 heading :
Testing Data
image2 heading :
Immunohistochemistry (IHC)
image3 heading :
Immunofluorescence (IF)
other info1 :
Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human CD88/C5aR around the phosphorylation site of serine 338(T-R-SP-T-V).
products categories :
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
products references :
W Fureder, J. Immunol., Sep 1995; 155: 3152. T Werfel, J. Immunol., Aug 1996; 157: 1729. Anthony A. Floreani, J. Immunol., May 1998; 160: 5073. M Burg, J. Immunol., Dec 1996; 157: 5574.
ncbi acc num :
NP_001727.1
ncbi gb acc num :
NM_001736.3
ncbi mol weight :
39,336 Da
ncbi pathways :
Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Peptide GPCRs Pathway (198897)
uniprot summary :
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).