antibody

AP4E1 Antibody

MBS859638

0.1 mg

320 USD

polyclonal

rabbit

nonconjugated

human, rat

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

AP4E1 Antibody

[AP4E1]

[Homo sapiens adaptor-related protein complex 4, epsilon 1 subunit, mRNA; AP-4 complex subunit epsilon-1; AP-4 complex subunit epsilon-1; adaptor related protein complex 4 subunit epsilon 1; AP-4 adaptor complex subunit epsilon; Adaptor-related protein complex 4 subunit epsilon-1; Epsilon subunit of AP-4; Epsilon-adaptin]

[AP4E1]

[AP4E1; AP4E1; CPSQ4; SPG51; STUT1]

Polyclonal

Rabbit

Human; Predicted: Mouse, Rat - Not yet tested in other species.

4075

Lyophilized AP4E1 anitbody purified by protein affinity column containing 1% BSA and 0.02% NaN3

Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

ELISA: 1:20,000-1:80,000. WB: 1:1,000-1:2,000. IHC: 1:100-1:500 . Optimal dilutions/concentrations should be determined by the end user.

Western Blot (WB)

Immunohistochemistry (IHC)

Source: Rabbit polyclonal AP4E1 antibody was raised against a recombinate human AP4E1 protein 951-1136aa (BC130466).

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

(1) Abou Jamra, R., Philippe, O. et al. Adaptor protein complex 4 deficiency causes severe autosomal-recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature. Am. J. Hum. Genet. 88 (6), 788-795 (2011).

120660383

BC130466

Clathrin Derived Vesicle Budding Pathway (119545); Golgi Associated Vesicle Biogenesis Pathway (119546); Lysosome Pathway (99052); Lysosome Pathway (96865); Membrane Trafficking Pathway (106160); Trans-Golgi Network Vesicle Budding Pathway (106165)

This gene encodes a member of the adaptor complexes large subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. The encoded protein is a large subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin-coated vesicles. Disruption of this gene may be associated with cerebral palsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable).

0.1 mg

320 USD