TGF beta Receptor I (Phospho-Ser165) Antibody | MyBioSource MBS859620 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

TGF beta Receptor I (Phospho-Ser165) Antibody

catalog :

MBS859620

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS859620

products type :

Antibody

products full name :

TGF beta Receptor I (Phospho-Ser165) Antibody

products short name :

TGF beta Receptor I

products name syn :

TGF b Receptor I (Phospho-Ser165) Antibody; ADRB2; ALK-5; Activin receptor-like kinase 5; ESK2; SKR4; TGF-beta receptor type I precursor; TGF-beta type I receptor; TGF-betaR1; TGFR-1; TGFR1; kinase TGF-beta-R1; receptor R4

other names :

TGF-beta receptor type-1 isoform 2; TGF-beta receptor type-1; TGF-beta receptor type-1; tbetaR-I; TGF-beta receptor type I; TGF-beta type I receptor; activin receptor-like kinase 5; multiple self-healing squamous epithelioma; transforming growth factor beta receptor I; serine/threonine-protein kinase receptor R4; activin A receptor type II-like kinase, 53kD; activin A receptor type II-like kinase, 53kDa; transforming growth factor-beta receptor type I; activin A receptor type II-like protein kinase of 53kD; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD); transforming growth factor, beta receptor 1; Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; ALK5; Serine/threonine-protein kinase receptor R4; SKR4; TGF-beta type I receptor; Transforming growth factor-beta receptor type I; TGF-beta receptor type I; TbetaR-I

other gene names :

TGFBR1; TGFBR1; AAT5; ALK5; ESS1; LDS1; MSSE; SKR4; ALK-5; LDS1A; LDS2A; TGFR-1; ACVRLK4; ALK5; SKR4; TGFR-1; ALK-5; ALK5; SKR4; TGF-beta receptor type I; TbetaR-I

uniprot entry name :

TGFR1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

426

specificity :

TGF beta Receptor I (Phospho-Ser165) antibody detects endogenous levels of TGF beta Receptor I only when phosphorylated at serine 165.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

1 mg/ml

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

IF: 1:100~1:500, ELISA: 1:5000

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human TGF beta Receptor I around the phosphorylation site of serine 165 (D-P-SP-L-D). All Sites: Human: Ser165; Mouse: Ser165; Rat: Ser163

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Franzen P., Cell 75:681-692(1993). Vellucci V.F., Genomics 46:278-283(1997). Lynch M.A., Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases. ----------------------------------------------------------------------------

ncbi gi num :

195963412

ncbi acc num :

NP_001124388.1

ncbi gb acc num :

NM_001130916.1

uniprot acc num :

P36897

ncbi mol weight :

47,690 Da

ncbi pathways :

ALK1 Signaling Events Pathway (137968); Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Chronic Myeloid Leukemia Pathway (83116); Chronic Myeloid Leukemia Pathway (528); Colorectal Cancer Pathway (83106); Colorectal Cancer Pathway (518); Cytokine-cytokine Receptor Interaction Pathway (83051)

ncbi summary :

The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

uniprot summary :

TGFBR1: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Found in all tissues; most abundant in placenta and least abundant in brain and heart. Protein type: Membrane protein, integral; EC 2.7.11.30; Protein kinase, TKL; Protein kinase, Ser/Thr (receptor); Kinase, protein; Receptor, misc.; TKL group; STKR family; Type1 subfamily. Chromosomal Location of Human Ortholog: 9q22. Cellular Component: tight junction; membrane; cell; plasma membrane; endosome; receptor complex. Molecular Function: transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; growth factor binding; metal ion binding; receptor signaling protein activity; punt binding; SMAD binding; ATP binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity. Biological Process: blastocyst development; collagen fibril organization; activation of MAPKK activity; heart development; positive regulation of transcription, DNA-dependent; negative regulation of chondrocyte differentiation; cell motility involved in cell locomotion; activin receptor signaling pathway; protein amino acid phosphorylation; post-embryonic development; anterior/posterior pattern formation; extracellular structure organization and biogenesis; transforming growth factor beta receptor signaling pathway; germ cell migration; kidney development; cell cycle arrest; neuron fate commitment; embryonic cranial skeleton morphogenesis; parathyroid gland development; positive regulation of cell growth; endothelial cell activation; mesenchymal cell differentiation; regulation of gene expression; negative regulation of endothelial cell proliferation; endothelial cell migration; positive regulation of endothelial cell proliferation; lens development in camera-type eye; wound healing; apoptosis; regulation of protein ubiquitination; palate development; signal transduction; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; angiogenesis; skeletal development; positive regulation of filopodium formation; pharyngeal system development; thymus development; in utero embryonic development; male gonad development; peptidyl-threonine phosphorylation; positive regulation of cell motility; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; skeletal morphogenesis; regulation of protein binding; epithelial to mesenchymal transition; artery morphogenesis; negative regulation of transforming growth factor beta receptor signaling pathway. Disease: Multiple Self-healing Squamous Epithelioma, Susceptibility To

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage