Pin1 (Phospho-Ser16) Antibody | MyBioSource MBS859597 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Pin1 (Phospho-Ser16) Antibody

catalog :

MBS859597

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS859597

products type :

Antibody

products full name :

Pin1 (Phospho-Ser16) Antibody

products short name :

Pin1

products name syn :

EC 5.2.1.8; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; PPIase Pin1; Rotamase Pin1

other names :

peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; PPIase Pin1; rotamase Pin1; protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1; peptidylprolyl cis/trans isomerase, NIMA-interacting 1; Peptidyl-prolyl cis-trans isomerase Pin1; PPIase Pin1; Rotamase Pin1

products gene name :

Pin1

other gene names :

PIN1; PIN1; DOD; UBL5; PPIase Pin1

uniprot entry name :

PIN1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

163

specificity :

Pin1 (Phospho-Ser16) antibody detects endogenous levels of Pin1 only when phosphorylated at serine 16.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation s

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

app notes :

WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:20000

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human Pin1 around the phosphorylation site of serine 16 (R-M-SP-R-S). All Sites: Human: Ser16; Mouse: Ser16

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Lu K.P., Nature 380:544-547(1996). Ebert L., Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases. The MGC Project Team; Genome Res. 14:2121-2127(2004).

ncbi gi num :

5453898

ncbi acc num :

NP_006212.1

ncbi gb acc num :

NM_006221.3

uniprot acc num :

Q13526

ncbi mol weight :

18,243 Da

ncbi pathways :

Antiviral Mechanism By IFN-stimulated Genes Pathway (530760); C-MYC Pathway (169344); Cytokine Signaling In Immune System Pathway (366171); ISG15 Antiviral Mechanism Pathway (530761); Immune System Pathway (106386); Innate Immune System Pathway (106387); Interferon Signaling Pathway (187103); Negative Regulators Of RIG-I/MDA5 Signaling Pathway (187102); RIG-I-like Receptor Signaling Pathway (117292); RIG-I-like Receptor Signaling Pathway (116128)

ncbi summary :

Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]

uniprot summary :

PIN1: a member of the parvulin family of peptidyl-prolyl isomerases (PPIase), has been implicated in the G2-M transition of the cell cycle. Has two distinct functional domains: an N-terminal WW domain and a C-terminal PPlase domain. Pin1 interacts with a series of mitotic phosphoproteins, including Plk1, cdc25C and cdc27, catalyzing pSer-Pro or pThr/Pro cis/trans isomerizations. Displays a preference for an acidic residue n-terminal to the isomerized proline bond. Protein type: EC 5.2.1.8; Nuclear receptor co-regulator; Isomerase. Chromosomal Location of Human Ortholog: 19p13. Cellular Component: nucleoplasm; cytoplasm; nuclear speck; midbody; nucleus. Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; mitogen-activated protein kinase kinase binding; phosphothreonine binding; GTPase activating protein binding; phosphoserine binding. Biological Process: protein peptidyl-prolyl isomerization; positive regulation of ubiquitin-protein ligase activity; cytokine and chemokine mediated signaling pathway; regulation of mitosis; innate immune response; positive regulation of protein amino acid phosphorylation; negative regulation of transforming growth factor beta receptor signaling pathway; cell cycle; negative regulation of interferon type I production; regulation of cytokinesis

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage