Kv4.2/KCND2 (Phospho-Ser616) Antibody | MyBioSource MBS859585 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Kv4.2/KCND2 (Phospho-Ser616) Antibody

catalog :

MBS859585

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS859585

products type :

Antibody

products full name :

Kv4.2/KCND2 (Phospho-Ser616) Antibody

products short name :

Kv4.2/KCND2

products name syn :

KCND2; KIAA1044; Potassium channel Kv4.2; Potassium voltage-gated channel subfamily D member 2

other names :

potassium voltage-gated channel subfamily D member 2; Potassium voltage-gated channel subfamily D member 2; potassium voltage-gated channel subfamily D member 2; voltage-sensitive potassium channel; voltage-gated potassium channel subunit Kv4.2; potassium voltage-gated channel, Shal-related subfamily, member 2; Voltage-gated potassium channel subunit Kv4.2

products gene name :

Kv4.2/KCND2

other gene names :

KCND2; KCND2; RK5; KV4.2; KIAA1044

uniprot entry name :

KCND2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

630

specificity :

Kv4.2/KCND2 (Phospho-Ser616) antibody detects endogenous levels of Kv4.2/KCND2 only when phosphorylated at serine 616.

purity :

affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

1mg/ml

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

IHC: 1:50~1:100, ELISA: 1:5000

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human Kv4.2/KCND2 around the phosphorylation site of serine 616 (P-E-SP-P-E). All Sites: Human: Ser616; Mouse: Ser616; Rat: Ser616

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Kong W., Am. J. Physiol. 275:H1963-H1970(1998). Kikuno R., DNA Res. 6:197-205(1999). Zhu X.-R., Recept. Channels 6:387-400(1999). ----------------------------------------------------------------------------

ncbi gi num :

9789987

ncbi acc num :

NP_036413.1

ncbi gb acc num :

NM_012281.2

uniprot acc num :

Q9NZV8

ncbi pathways :

Neuronal System Pathway (106513); Potassium Channels Pathway (366221); Serotonergic Synapse Pathway (525336); Voltage Gated Potassium Channels Pathway (366230)

ncbi summary :

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. [provided by RefSeq, Jul 2008]

uniprot summary :

Kv4.2: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassium. Chromosomal Location of Human Ortholog: 7q31. Cellular Component: postsynaptic membrane; voltage-gated potassium channel complex; integral to plasma membrane; plasma membrane; integral to membrane; dendritic spine; intrinsic to plasma membrane. Molecular Function: protein binding; voltage-gated potassium channel activity; delayed rectifier potassium channel activity; metal ion binding; A-type (transient outward) potassium channel activity. Biological Process: regulation of action potential; synaptic transmission; protein homooligomerization

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage