antibody

CD130/gp130 (Ab-782) Antibody

MBS859145

0.1 mg

215 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

CD130/gp130 (Ab-782) Antibody

CD130/gp130

CD130; CDw130; GP130; IL-6R-beta; IL6B; IL6RB; IL6ST; Interleukin 6 signal transducer; Interleukin-6 receptor beta chain precursor; Membrane glycoprotein 130; Oncostatin M receptor

interleukin-6 receptor subunit beta isoform 3; Interleukin-6 receptor subunit beta; interleukin-6 receptor subunit beta; CD130 antigen; IL-6R subunit beta; membrane glycoprotein 130; IL-6 receptor subunit beta; membrane glycoprotein gp130; gp130, oncostatin M receptor; interleukin receptor beta chain; oncostatin-M receptor subunit alpha; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; interleukin 6 signal transducer; CDw130; Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; Oncostatin-M receptor subunit alpha; CD_antigen: CD130

CD130/gp130

IL6ST; IL6ST; CD130; GP130; CDW130; IL-6RB; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; gp130

IL6RB_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse

857

CD130/gp130 (Ab-782) antibody detects endogenous levels of total CD130/gp130 protein.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at -20 degree C for 1 year

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

WB: 1:500~1:3000, IHC: 1:50~1:100, IF: 1:100~1:500, ELISA: 1:20000

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human CD130/gp130 around the phosphorylation site of serine 782 (S-E-SP-T-Q).

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

Hans-Heinrich Oberg, Int. Immunol., Apr 2006; 18: 555 - 563. Ursula Horsten, J. Biol. Chem., Sep 1997; 272: 23748. Gerhard Mller-Newen, J. Immunol., Dec 1998; 161: 6347. UA Betz, Int. Immunol., Aug 1998; 10: 1175 - 1184.

300244535

NP_001177910.1

NM_001190981.1

P40189

96,276 Da

Adipogenesis Pathway (198832); Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); IL-6 Signaling Pathway (198864); IL27-mediated Signaling Events Pathway (137929); IL6-mediated Signaling Events Pathway (137932); Immune System Pathway (106386); Interleukin-11 Signaling Pathway (698753); Interleukin-6 Signaling Pathway (205111)

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]

gp130: gp130 is a ubiquitously expressed type I cytokine family receptor. The receptor systems for IL6, LIF, OSM, CNTF, IL11 AND CT1 utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not directly bind IL6. May have a role in embryonic development. Contains 5 fibronectin type III domains and 1 immunoglobulin-like C2-type domain. Two alternatively spliced isoforms have been described. Protein type: Receptor, cytokine; Membrane protein, integral. Chromosomal Location of Human Ortholog: 5q11.2. Cellular Component: extracellular space; cell soma; membrane; oncostatin-M receptor complex; dendrite; plasma membrane; extracellular region; interleukin-6 receptor complex; external side of plasma membrane. Molecular Function: interleukin-11 binding; protein binding; protein homodimerization activity; interleukin-6 binding; interleukin-27 receptor activity; interleukin-6 receptor binding; oncostatin-M receptor activity; leukemia inhibitory factor receptor activity; growth factor binding; ciliary neurotrophic factor receptor activity; interleukin-6 receptor activity; ciliary neurotrophic factor receptor binding; interleukin-11 receptor activity. Biological Process: glycogen metabolic process; viral reproduction; cytokine and chemokine mediated signaling pathway; leukemia inhibitory factor signaling pathway; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of osteoblast differentiation; positive regulation of tyrosine phosphorylation of Stat1 protein; regulation of Notch signaling pathway; positive regulation of acute inflammatory response; response to cytokine stimulus; positive regulation of cell proliferation; positive regulation of T cell proliferation; positive regulation of adaptive immune response; positive regulation of astrocyte differentiation; negative regulation of apoptosis

0.1 mg

215 USD