catalog number :
MBS858995
products full name :
ARHGEF17 Antibody
products short name :
[ARHGEF17]
products name syn :
[Rho guanine nucleotide exchange factor 17; 164 kDa Rho-specific guanine-nucleotide exchange factor; p164RhoGEF; p164-RhoGEF; Tumor endothelial marker 4; ARHGEF17; KIAA0337; TEM4]
other names :
[stathmin isoform b; Stathmin; stathmin; stathmin 1; Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; pp19; Prosolin; Protein Pr22; pp17]
products gene name :
[ARHGEF17]
other gene names :
[STMN1; STMN1; Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215; C1orf215; LAP18; OP18; Op18; pp19]
reactivity :
Human (Identifies = 100%, Positives = 100%). Mouse (Identifies = 100%, Positives = 100%)
specificity :
ARHGEF17 antibody detects endogenous levels of total ARHGEF17 protein.
purity :
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at-20 degree C for 1 year.
tested application :
Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
app notes :
IHC: 1:50-1:100. IF: 1:00-1:500. ELISA: 1:5000
image1 heading :
Testing Data
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: The antiserum was produced against synthesized peptide derived from internal of human ARHGEF17.
products categories :
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
products references :
Carson-Walter E.B., Cancer Res. 61:6649-6655(2001). Ota T., Nat. Genet. 36:40-45(2004). Nagase T., DNA Res. 4:141-150(1997).
ncbi acc num :
NP_001138926.1
ncbi gb acc num :
NM_001145454.2
ncbi pathways :
Aurora B Signaling Pathway (138080); Integrated Pancreatic Cancer Pathway (711360); MAPK Signaling Pathway (198779); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); Regulation Of Microtubule Cytoskeleton Pathway (755439); Signaling Mediated By P38-gamma And P38-delta Pathway (138043)
ncbi summary :
This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
uniprot summary :
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear ().