antibody

sgo2 Antibody

MBS858924

0.1 mL

290 USD

polyclonal

rabbit

nonconjugated

ELISA, immunohistochemistry, enzyme immunoassay

Antibody

sgo2 Antibody

[sgo2]

[SGOL2, Shugoshin-like 2; Shugoshin-2; Sgo2; Tripin.]

[G1/S-specific cyclin-E1 isoform 1; G1/S-specific cyclin-E1; G1/S-specific cyclin-E1; cyclin E1]

[sgo2]

[CCNE1; CCNE1; CCNE; pCCNE1; CCNE]

polyclonal

IgG

rabbit

Human

410

Sgo2 Polyclonal Antibody detects endogenous levels of Sgo2 protein.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

1 mg/mL

Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC), ELISA (EIA)

Dilution: Immunohistochemisty: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Western Blot (WB)

Immunogen: Synthesized peptide derived from the Internal region of human Sgo. at AA rangle: 650-730.

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

Cyclin E1 (CCNE1) is a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. CCNE1, an essential cyclin activating Cdk2, regulates the G1-S phase transition of the mammalian cell division cycle. Its timing expression plays a direct role in the initiation of DNA replication, the control of histone biosynthesis, and the centrosome cycle. CCNE1 is associated with disease progression in various malignancies and is associated clinically with poor prognosis.

17318559

NP_001229.1

NM_001238.3

P24864

144.739

Androgen Receptor Signaling Pathway (198806); B Cell Receptor Signaling Pathway (198909); BARD1 Signaling Events Pathway (137959); Cell Cycle Pathway (530733); Cell Cycle Checkpoints Pathway (105739); Cell Cycle, Mitotic Pathway (105765); Cell Cycle Pathway (198811); Cell Cycle Pathway (83054); Cell Cycle Pathway (463); Cyclin A:Cdk2-associated Events At S Phase Entry Pathway (105783)

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]

Essential for the control of the cell cycle at the G1/S (start) transition.

0.1 mL

290 USD