PP2A-alpha (Ab-307) Antibody | MyBioSource MBS858915 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PP2A-alpha (Ab-307) Antibody

catalog :

MBS858915

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS858915

products type :

Antibody

products full name :

PP2A-alpha (Ab-307) Antibody

products short name :

PP2A-alpha

products name syn :

PP2A-a (Ab-307) Antibody; EC 3.1.3.16; PP2A-alpha; PP2AA; RP-C; Replication protein C; Serine/threonine protein phosphatase 2A; catalytic subunit; alpha isoform

other names :

serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A-alpha; replication protein C; protein phosphatase 2A catalytic subunit, alpha isoform; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isozyme; Replication protein C; RP-C

products gene name :

PP2A-alpha

other gene names :

PPP2CA; PPP2CA; RP-C; PP2Ac; PP2CA; PP2Calpha; PP2A-alpha; RP-C

uniprot entry name :

PP2AA_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

309

specificity :

PP2A-alpha (Ab-307) antibody detects endogenous levels of total PP2A-alpha protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

app notes :

WB: 1:500~1:1000, IHC: 1:50~1:100, IF: 1:100~1:500, ELISA: 1:5000

other info2 :

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human PP2A-alpha around the phosphorylation site of tyrosine 307 (P-D-YP-F-L).

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Wen Chen, Cancer Res., Sep 2005; 65: 8183 - 8192. Kathy Bonness, Mol. Cancer Ther., Nov 2006; 5: 2727 - 2736. Stefaan Wera, J. Biol. Chem., Sep 1995; 270: 21374. Todd D. Prickett, J. Biol. Chem., Sep 2004; 279: 38912 - 38920.

ncbi gi num :

4506017

ncbi acc num :

NP_002706.1

ncbi gb acc num :

NM_002715.2

uniprot acc num :

P67775

ncbi mol weight :

29,735 Da

ncbi pathways :

AMER1 Mutants Destabilize The Destruction Complex Pathway (1016198); AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway (1016193); APC Truncation Mutants Have Impaired AXIN Binding Pathway (1016194); AXIN Missense Mutants Destabilize The Destruction Complex Pathway (1016197); AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway (1016195); Activated TLR4 Signalling Pathway (106400); Adaptive Immune System Pathway (366160); Adrenergic Signaling In Cardiomyocytes Pathway (908257)

ncbi summary :

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]

uniprot summary :

PPP2CA: ubiquitous cytosolic Ser/Thr protein phosphatase, catalytic subunit. The holoenzyme consists of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B /PR72/PR130/PR59 and R5/B /B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Protein type: Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16. Chromosomal Location of Human Ortholog: 5q31.1. Cellular Component: microtubule cytoskeleton; spindle pole; protein phosphatase type 2A complex; membrane; mitochondrion; plasma membrane; cytosol; nucleus; chromosome, pericentric region. Molecular Function: protein dimerization activity; protein C-terminus binding; protein binding; metal ion binding; GABA receptor binding; protein serine/threonine phosphatase activity. Biological Process: mitotic nuclear envelope reassembly; apoptosis; regulation of protein amino acid autophosphorylation; protein amino acid dephosphorylation; response to organic substance; regulation of transcription, DNA-dependent; meiotic cell cycle; regulation of cell differentiation; regulation of growth; mesoderm development; regulation of receptor activity; regulation of DNA replication; inactivation of MAPK activity; regulation of cell adhesion; second-messenger-mediated signaling; fibroblast growth factor receptor signaling pathway; RNA splicing; regulation of Wnt receptor signaling pathway; negative regulation of tyrosine phosphorylation of Stat3 protein; mRNA catabolic process, nonsense-mediated decay; gene expression; regulation of protein catabolic process; mitotic cell cycle; negative regulation of cell growth; ceramide metabolic process

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage