NFAT2 (Phospho-Ser294) Antibody | MyBioSource MBS858878 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

NFAT2 (Phospho-Ser294) Antibody

catalog :

MBS858878

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS858878

products type :

Antibody

products full name :

NFAT2 (Phospho-Ser294) Antibody

products short name :

NFAT2

products name syn :

NF-ATc; NF-ATc1; NFAC1; NFAT transcription complex cytosolic component; NFATC; NFATC1; NFC1; Nuclear factor of activated T-cells cytoplasmic 1

other names :

nuclear factor of activated T-cells, cytoplasmic 1 isoform F; Nuclear factor of activated T-cells, cytoplasmic 1; nuclear factor of activated T-cells, cytoplasmic 1; NFAT transcription complex cytosolic component; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1; NFAT transcription complex cytosolic component; NF-ATc; NFATc

products gene name :

NFAT2

other gene names :

NFATC1; NFATC1; NFAT2; NFATc; NF-ATC; NFAT2; NFATC; NF-ATc1; NFATc1; NF-ATc; NFATc

uniprot entry name :

NFAC1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

943

specificity :

NFAT2 (Phospho-Ser294) antibody detects endogenous levels of NFAT2 only when phosphorylated at serine 294.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

IHC: 1:50~1:100, ELISA: 1:1000

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human NFAT2 around the phosphorylation site of serine 294 (R-V-SP-V-T). All Sites: Human: Ser294; Mouse: Ser296

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Gauci S., Anal. Chem. 81:4493-4501(2009). Northrop J.P., Nature 369:497-502(1994).

ncbi gi num :

522021835

ncbi acc num :

NP_001265598.1

ncbi gb acc num :

NM_001278669.1

uniprot acc num :

O95644

ncbi mol weight :

38,626 Da

ncbi pathways :

B Cell Receptor Signaling Pathway (198909); B Cell Receptor Signaling Pathway (83081); B Cell Receptor Signaling Pathway (492); BCR Signaling Pathway (138058); Ca2+ Pathway (941399); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Calcium Signaling In The CD4+ TCR Pathway (137941); Downstream Signaling In Naive CD8+ T Cells Pathway (138018); FCERI Mediated Ca+2 Mobilization Pathway (833827); Fc Epsilon Receptor (FCERI) Signaling Pathway (833825)

ncbi summary :

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]

uniprot summary :

NFAT2: a transcription factor that plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4. Also control gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of lymphoid and nonlymphoid cells. Six splice variant isoforms have been identified. Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T-cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T-cells after second antigen exposure. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 18q23. Cellular Component: nucleoplasm; transcription factor complex; nuclear chromatin; cytoplasm; cytosol; nucleus. Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; FK506 binding; mitogen-activated protein kinase p38 binding; transcription factor activity. Biological Process: transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; heart development; calcium ion transport; innate immune response; epithelial to mesenchymal transition; positive regulation of transcription from RNA polymerase II promoter; osteoclast differentiation; G1/S transition of mitotic cell cycle

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage