catalog number :
MBS858824
products full name :
Moesin/Ezrin/Radixin (Ab-558) Antibody
products short name :
[Moesin/Ezrin/Radixin]
products name syn :
[MOES; Membrane-organizing extension spike protein]
other names :
[moesin; Moesin; moesin; moesin; Membrane-organizing extension spike protein]
products gene name :
[MSN]
other gene names :
[MSN; MSN; HEL70; IMD50]
reactivity :
Human, Mouse, Rat
specificity :
Moesin/Ezrin/Radixin (Ab-558) antibody detects endogenous levels of total Moesin/Ezrin/Radixin protein.
purity :
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at-20 degree C for 1 year.
tested application :
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
app notes :
WB: 1:500~1:1000. IHC: 1:50~1:100. ELISA: 1:20000
image1 heading :
Testing Data
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human Moesin/Ezrin/Radixin around the phosphorylation site of threonine 558 (Y-K-TP-L-R).
products categories :
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
products references :
Lankes W.T., Proc. Natl. Acad. Sci. U.S.A. 88:8297-8301(1991). Ross M.T., Nature 434:325-337(2005). Kim S.C., Mol. Cell 23:607-618(2006).
ncbi acc num :
NP_002435.1
ncbi gb acc num :
NM_002444.2
ncbi mol weight :
67,820 Da
ncbi pathways :
AGE/RAGE Pathway (698754); Axon Guidance Pathway (105688); Developmental Biology Pathway (477129); Glial Cell Differentiation Pathway (698758); L1CAM Interactions Pathway (161003); Leukocyte Transendothelial Migration Pathway (83083); Leukocyte Transendothelial Migration Pathway (494); Measles Pathway (213306); Measles Pathway (213277); Plasma Membrane Estrogen Receptor Signaling Pathway (138009)
ncbi summary :
Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]
uniprot summary :
Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage. Plays a role in regulating the proliferation, migration, and adhesion of human lymphoid cells and participates in immunologic synapse formation (PubMed:27405666).