VAV1 (Phospho-Tyr160) Antibody | MyBioSource MBS858667 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

VAV1 (Phospho-Tyr160) Antibody

catalog :

MBS858667

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS858667

products type :

Antibody

products full name :

VAV1 (Phospho-Tyr160) Antibody

products short name :

VAV1

products name syn :

Proto-oncogene vav; VAV1; VAV

other names :

proto-oncogene vav isoform 3; Proto-oncogene vav; proto-oncogene vav; vav 1 oncogene; vav 1 guanine nucleotide exchange factor

products gene name :

VAV1

other gene names :

VAV1; VAV1; VAV; VAV

uniprot entry name :

VAV_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

813

specificity :

VAV1 (Phospho-Tyr160) antibody detects endogenous levels of VAV1 only when phosphorylated at tyrosine 160.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

IHC: 1:50~1:100, ELISA: 1:5000

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human VAV1 around the phosphorylation site of tyrosine 160 (D-L-YP-D-C). All Sites: Human: Tyr160; Mouse: Tyr160; Rat: Tyr160

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Katzav S., Mol. Cell. Biol. 11:1912-1920(1991). Denkinger D.J., Biochim. Biophys. Acta 1491:253-262(2000). Coppola J., Cell Growth Differ. 2:95-105(1991). ------------------------------------------------------------------------------------------------------------------------------------------

ncbi gi num :

384551649

ncbi acc num :

NP_001245136.1

ncbi gb acc num :

NM_001258207.1

uniprot acc num :

P15498

ncbi mol weight :

94,493 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway (576249); B Cell Receptor Signaling Pathway (198909); B Cell Receptor Signaling Pathway (83081); B Cell Receptor Signaling Pathway (492); CD28 Co-stimulation Pathway (119553); CD28 Dependent Vav1 Pathway (119555); CXCR4-mediated Signaling Events Pathway (137910); Cell Death Signalling Via NRAGE, NRIF And NADE Pathway (106443); Chemokine Signaling Pathway (99051)

ncbi summary :

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]

uniprot summary :

VAV1: a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed exclusively in hematopoietic cells. Important in hematopoiesis, playing a role in T-cell and B-cell development and activation. Protein type: GEFs, Rac/Rho; GEFs; Motility/polarity/chemotaxis; Oncoprotein. Chromosomal Location of Human Ortholog: 19p13.2. Cellular Component: plasma membrane; intercellular junction; cytosol. Molecular Function: protein binding; metal ion binding; Rac guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; transcription factor activity. Biological Process: epidermal growth factor receptor signaling pathway; integrin-mediated signaling pathway; platelet activation; neutrophil chemotaxis; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; T cell activation; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; G-protein coupled receptor protein signaling pathway; regulation of small GTPase mediated signal transduction; regulation of transcription, DNA-dependent; small GTPase mediated signal transduction; T cell costimulation; innate immune response; blood coagulation; vascular endothelial growth factor receptor signaling pathway

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage