product summary
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company name :
MyBioSource
product type :
other
product name :
MLKL Antibody
catalog :
MBS858387
quantity :
0.1 mg
price :
280 USD
more info or order :
MyBioSource product webpage
image
image 1 :
MyBioSource MBS858387 image 1
Western blot analysis of extracts from HeLa cells and K562 cells, using MLKL antibody.
product information
catalog number :
MBS858387
products type :
Antibody
products full name :
MLKL Antibody
products short name :
[MLKL]
products name syn :
[FLJ34389; mixed lineage kinase domain-like; Mixed lineage kinase domain-like protein; MLKL]
other names :
[mixed lineage kinase domain-like protein isoform 2; Mixed lineage kinase domain-like protein; mixed lineage kinase domain-like protein; mixed lineage kinase domain like pseudokinase]
products gene name :
[MLKL]
other gene names :
[MLKL; MLKL; hMLKL; hMLKL]
reactivity :
Human, Mouse, Rat
sequence length :
263
specificity :
MLKL antibody detects endogenous levels of total MLKL protein.
purity :
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at-20 degree C for 1 year.
tested application :
Western Blot (WB), ELISA (EIA)
app notes :
WB: 1:500-1:1000. ELISA: 1:1000
image1 heading :
Testing Data
other info1 :
Immunogen: The antiserum was produced against synthesized peptide derived from N-terminal of human MLKL.
products categories :
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
products references :
Manning G., Science 298:1912-1934(2002). Ota T., Nat. Genet. 36:40-45(2004). Martin J., Nature 432:988-994(2004).
ncbi gi num :
215820622
ncbi acc num :
NP_001135969.1
ncbi gb acc num :
NM_001142497.2
uniprot acc num :
Q8NB16
ncbi mol weight :
30,279 Da
ncbi pathways :
DNA Damage Response (only ATM Dependent) Pathway (198827); TNF Signaling Pathway (812256); TNF Signaling Pathway (813210)
ncbi summary :
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
uniprot summary :
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
size1 :
0.1 mg
price1 :
280 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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