antibody

TBLR1 (TBL1XR1) Antibody

MBS857924

0.1 mg

310 USD

monoclonal

mouse

nonconjugated

human, mouse, rat, dog, cow

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

TBLR1 (TBL1XR1) Antibody

TBLR1

C21; DC42; IRA1; FLJ12894

Homo sapiens nuclear receptor co-repressor/HDAC3 complex subunit TBLR1 (TBLR1) mRNA, complete cds; F-box-like/WD repeat-containing protein TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1; TBL1-related protein 1; transducin beta-like 1X-related protein 1; nuclear receptor co-repressor/HDAC3 complex subunit; nuclear receptor corepressor/HDAC3 complex subunit TBLR1; transducin (beta)-like 1 X-linked receptor 1; Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1-related protein 1; Transducin beta-like 1X-related protein 1

TBLR1

TBLR1

TBL1XR1; TBL1XR1; C21; DC42; IRA1; TBLR1; IRA1; TBLR1

TBL1R_HUMAN

Monoclonal

IgG1

Mouse

Human, Mouse, Rat, Bovine, Pig, Dog, Zebrafish

1745

This antibody detects endogenous levels TBLR1 and does not cross-react with related proteins.

Affinity purified

Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Uniprot Summary: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, th ereby allowing cofactor exchange, and transcription activation.

Immunogen: Purified recombinant human TBLR1 protein fragments expressed in E.coli. Entrez Summary: TBLR1 is an F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. It plays an essential role in transcription activation mediated by nuclear receptors and probably acts as an integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteosomal degradation of the N-Cor complex, thereby allowing cofactor exchange, and transcription activation. Cellular Localization: Nucleus

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

12642595

AF314544

Q9BZK7

60kDa

Activation Of Gene Expression By SREBF (SREBP) Pathway (685552); BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway (477138); Chromatin Modifying Enzymes Pathway (941403); Chromatin Organization Pathway (941402); Circadian Clock Pathway (187173); Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway (771595); Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway (771593); Developmental Biology Pathway (477129); Disease Pathway (530764); FBXW7 Mutants And NOTCH1 In Cancer Pathway (771596)

The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. [provided by RefSeq, Jul 2008]

TBL1XR1: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Probable component of some E3 ubiquitin ligase complex. Interacts with histones H2B and H4. Ubiquitous. Belongs to the WD repeat EBI family. Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor. Chromosomal Location of Human Ortholog: 3q26.32. Cellular Component: nucleoplasm; transcriptional repressor complex; spindle microtubule; histone deacetylase complex; nucleus. Molecular Function: protein binding; histone binding; beta-catenin binding; protein N-terminus binding; transcription corepressor activity. Biological Process: proteasomal ubiquitin-dependent protein catabolic process; Notch signaling pathway; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; histone deacetylation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; cellular lipid metabolic process

0.1 mg

310 USD