This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
Tsc2 (Ab-1254) Antibody
catalog :
MBS857690
quantity :
0.05 mg
price :
180 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry
product information
catalog number :
MBS857690
products type :
Antibody
products full name :
Tsc2 (Ab-1254) Antibody
products short name :
Tsc2
other names :
tuberin isoform 1; Tuberin; tuberin; tuberous sclerosis 2 protein; protein phosphatase 1, regulatory subunit 160; tuberous sclerosis 2; Tuberous sclerosis 2 protein
products gene name :
Tsc2
other gene names :
TSC2; TSC2; LAM; TSC4; PPP1R160; TSC4
uniprot entry name :
TSC2_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human
sequence length :
1807
specificity :
Tsc2 (Ab-1254) antibody detects endogenous levels of total Tsc2 protein.
purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
concentration :
50ug/50ul
storage stability :
Store at -20 degree C for 1 year
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:20000
other info2 :
Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human Tsc2 around the phosphorylation site of serine 1254. Pathway: Tumor suppressor
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
Cai SL, et al. (2006) J Cell Biol 173, 279-89. Roux PP, et al. (2004) Proc Natl Acad Sci USA 101, 13489-94. Li Y, Inoki K, Vacratsis P, Guan KL (2003) J Biol Chem 278, 13663-71. Manning BD, et al. (2002) Mol Cell 10, 151-62. Goncharova, E. et al. (2002) J. Biol. Chem. 277, 30958-30967. Aicher, L. D. et al. (2001) J. Biol. Chem. 276, 21017-21021.
ncbi gi num :
116256352
ncbi acc num :
NP_000539.2
ncbi gb acc num :
NM_000548.3
uniprot acc num :
P49815
ncbi mol weight :
25,773 Da
ncbi pathways :
AKT Phosphorylates Targets In The Cytosol Pathway 106475!!AMPK Signaling Pathway 198868!!AMPK Signaling Pathway 989139!!AMPK Signaling Pathway 992181!!Adaptive Immune System Pathway 366160!!BDNF Signaling Pathway 712093!!Constitutive PI3K/AKT Signaling In Cancer Pathway 685535!!DAP12 Interactions Pathway 685549!!DAP12 Signaling Pathway 685550!!Direct P53 Effectors Pathway 137939
ncbi summary :
Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
size :
0.05 mg
price :
180 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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