CREB (Ab-129) Antibody | MyBioSource MBS857584 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CREB (Ab-129) Antibody

catalog :

MBS857584

quantity :

0.05 mg

price :

180 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS857584

products type :

Antibody

products full name :

CREB (Ab-129) Antibody

products short name :

CREB

other names :

cyclic AMP-responsive element-binding protein 1 isoform A; Cyclic AMP-responsive element-binding protein 1; cyclic AMP-responsive element-binding protein 1; CREB-1; transactivator protein; active transcription factor CREB; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; cAMP responsive element binding protein 1

products gene name :

CREB

other gene names :

CREB1; CREB1; CREB; CREB-1; cAMP-responsive element-binding protein 1

uniprot entry name :

CREB1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

327

specificity :

CREB (Ab-129) antibody detects endogenous levels of total CREB protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

50ug/50ul

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:500~1:1000, IHC: 1:50~1:100

other info2 :

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human CREB around the phosphorylation site of serine 129 (I-L-SP-R-R). Pathway: MAPK, Cancer/Apoptosis, Chromatin/Transcription, Neuroscience

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Chrystelle V. Garat, et al. (2006) Mol. Cell. Biol ; 26: 4934 - 4948. Lilah Rothem,et al. (2004) Mol. Pharmacol ; 66: 1536 - 1543. Darren R. Tyson, et,al. (2002) Endocrinology; 143: 674. Kyung-Woo Park, et al. (2003) Arterioscler. Thromb. Vasc. Biol ; 23: 1364.

ncbi gi num :

4758054

ncbi acc num :

NP_004370.1

ncbi gb acc num :

NM_004379.3

uniprot acc num :

P16220

ncbi mol weight :

25,445 Da

ncbi pathways :

AKT Phosphorylates Targets In The Nucleus Pathway (106476); AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); ATF-2 Transcription Factor Network Pathway (138006); ATM Signaling Pathway (920969); Activated TLR4 Signalling Pathway (106400); Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (161033); Adaptive Immune System Pathway (366160); Adipogenesis Pathway (198832); Adrenergic Signaling In Cardiomyocytes Pathway (908257)

ncbi summary :

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

uniprot summary :

CREB: a transcription factor of the leucine zipper family of DNA binding proteins. Binds as a homodimer to the cAMP-responsive element (CRE). Phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Two splice-variant isoforms have been described. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 2q34. Cellular Component: nucleoplasm; nucleus. Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; enzyme binding; transcription cofactor activity; transcription factor activity. Biological Process: lactation; transcription from RNA polymerase II promoter; circadian rhythm; axon guidance; response to glucagon stimulus; nerve growth factor receptor signaling pathway; viral reproduction; positive regulation of osteoclast differentiation; positive regulation of transcription, DNA-dependent; stress-activated MAPK cascade; positive regulation of multicellular organism growth; toll-like receptor 3 signaling pathway; signal transduction; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; response to organic substance; toll-like receptor 5 signaling pathway; synaptic transmission; toll-like receptor 4 signaling pathway; epidermal growth factor receptor signaling pathway; response to drug; mitochondrion organization and biogenesis; Notch signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; protein stabilization; secretory granule organization and biogenesis; MyD88-independent toll-like receptor signaling pathway; organelle organization and biogenesis; positive regulation of hormone secretion; positive regulation of lipid biosynthetic process; memory; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; phospholipase C activation; pituitary gland development; toll-like receptor signaling pathway; innate immune response; positive regulation of fat cell differentiation; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; regulation of cell size. Disease: Histiocytoma, Angiomatoid Fibrous

size1 :

0.05 mg

price1 :

180 USD

size2 :

0.1 mg

price2 :

215

more info or order :

MyBioSource product webpage