MAPKAPK-2 (Phospho-Thr334) Antibody | MyBioSource MBS857571 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MAPKAPK-2 (Phospho-Thr334) Antibody

catalog :

MBS857571

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS857571

products type :

Antibody

products full name :

MAPKAPK-2 (Phospho-Thr334) Antibody

products short name :

MAPKAPK-2

other names :

MAP kinase-activated protein kinase 2 isoform 1; MAP kinase-activated protein kinase 2; MAP kinase-activated protein kinase 2; MAPKAP kinase 2; MAPK-activated protein kinase 2; mitogen-activated protein kinase-activated protein kinase 2

products gene name :

MAPKAPK-2

other gene names :

MAPKAPK2; MAPKAPK2; MK2; MK-2; MAPKAP-K2; MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAP-K2; MAPKAPK-2; MK-2; MK2

uniprot entry name :

MAPK2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

370

specificity :

MAPKAPK-2 (Phospho-Thr334) antibody detects endogenous levels of MAPKAPK-2 only when phosphorylated at threonine 334.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

50ug/50ul

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

WB: 1:500~1:1000, IHC: 1:50-1:100

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human MAPKAPK-2 around the phosphorylation site of threonine 334 (P-Q-TP-P-L). Pathway: MAPK, Kinase/Phosphatases

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Rouse, J. et al. (1994) Cell 78, 1027-1037. Ben-Levy, R. et al. (1995) EMBO J. 14, 5920-5930.

ncbi gi num :

10863901

ncbi acc num :

NP_004750.1

ncbi gb acc num :

NM_004759.4

uniprot acc num :

P49137

ncbi mol weight :

42,203 Da

ncbi pathways :

Activated TLR4 Signalling Pathway (106400); Arachidonic Acid Metabolism Pathway (685553); B Cell Receptor Signaling Pathway (198909); Butyrate Response Factor 1 (BRF1) Destabilizes MRNA Pathway (187213); CREB Phosphorylation Pathway (106484); Cellular Senescence Pathway (905991); Cellular Response To Heat Stress Pathway (980470); Cellular Responses To Stress Pathway (645258); FAS Pathway And Stress Induction Of HSP Regulation (198894); Gene Expression Pathway (105937)

ncbi summary :

This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

MAPKAPK2: a member of the MAPKAPK family of protein kinases. It is phosphorylated and activated by p38 in response to cytokines, stress and chemotactic factors.MAPKAPK-2 is apparently a direct target of p38 MAPK. HSP27 is one of its in vivo substrates. Two transcript variants encoding two different isoforms have been described. Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; CAMK group; MAPKAPK family; MAPKAPK subfamily. Chromosomal Location of Human Ortholog: 1q32. Cellular Component: nucleoplasm; centrosome; cytoplasm; cytosol; nucleus. Molecular Function: protein serine/threonine kinase activity; protein binding; signal transducer activity; ATP binding; protein kinase activity. Biological Process: nerve growth factor receptor signaling pathway; activation of MAPK activity; stress-activated MAPK cascade; leukotriene metabolic process; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; regulation of interleukin-6 production; response to stress; arachidonic acid metabolic process; inflammatory response; inner ear development; toll-like receptor 4 signaling pathway; MyD88-independent toll-like receptor signaling pathway; MAPKKK cascade; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; peptidyl-serine phosphorylation; response to cytokine stimulus; Ras protein signal transduction; toll-like receptor signaling pathway; innate immune response; regulation of tumor necrosis factor production; gene expression; toll-like receptor 9 signaling pathway; G2/M transition DNA damage checkpoint; vascular endothelial growth factor receptor signaling pathway; response to DNA damage stimulus

size1 :

0.1 mg

price1 :

215 USD

size2 :

0.05 mg

price2 :

225

more info or order :

MyBioSource product webpage