antibody

IKBKE Antibody

MBS857529

0.1 mg

290 USD

polyclonal

rabbit

nonconjugated

western blot, immunohistochemistry

Antibody

IKBKE Antibody

IKBKE

IKBKE; IKK-E; IKK-i; IKKE; IKKI; KIAA0151; MGC125294; MGC125295; MGC125297

IKBKE

IgG

Rabbit

Human, mouse, rat

Affinity purification

Store at -20 degree C or -80 degree C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Western Blot (WB), Immunohistochemistry (IHC)

WB 1:500 - 1:2000; IHC 1:50- 1:200

Immunogen: Recombinant proteinof human IKBKE. Gene ID: 9641

IKK epsilon is a noncanonical I-kappa-B kinase (IKK) that is essential for regulating antiviral signaling pathways. It has also been identified as a breast cancer oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (1). IKK epsilon phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. It plays a special role in the immune response. IKK epsilon protects cells against DNA damage-induced cell death.

Q14164

80kDa

IKKE: a oncogenic kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Plays a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response. Its redistribution to PML nuclear bodies upon DNA damage is TOPORS-dependent. Is a breast cancer oncogene that exerts its oncogenic properties through cRel. Protein type: Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Inhibitor; EC 2.7.11.10; Other group; IKK family. Chromosomal Location of Human Ortholog: 1q32.1. Cellular Component: nucleoplasm; PML body; cytoplasm; mitochondrial membrane; endosome membrane; nucleus; cytosol. Molecular Function: NF-kappaB-inducing kinase activity; protein binding; IkappaB kinase activity; ATP binding. Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; DNA damage response, signal transduction resulting in induction of apoptosis; MyD88-independent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; immune response; toll-like receptor 3 signaling pathway; I-kappaB phosphorylation; toll-like receptor 4 signaling pathway; protein amino acid phosphorylation; negative regulation of interferon type I production

0.1 mg

290 USD