catalog number :
MBS857447
products full name :
VEGFR2 (Ab-1175) Antibody
products short name :
VEGFR2
other names :
vascular endothelial growth factor receptor 2; Vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor 2; soluble VEGFR2; fetal liver kinase 1; fetal liver kinase-1; protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factor receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; KDR; Protein-tyrosine kinase receptor flk-1; CD_antigen: CD309
products gene name :
VEGFR2
other gene names :
KDR; KDR; FLK1; CD309; VEGFR; VEGFR2; FLK1; VEGFR2; VEGFR-2; FLK-1; KDR
uniprot entry name :
VGFR2_HUMAN
reactivity :
Human, Mouse, Rat
specificity :
VEGFR2 (Ab-1175) antibody detects endogenous levels of total VEGFR2 protein.
purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
concentration :
50ug/50ul
storage stability :
Store at -20 degree C for 1 year
tested application :
Immunohistochemistry (IHC), Immunofluorescence (IF)
app notes :
IHC: 1:50~1:100, IF:1:100~1:200
other info2 :
Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human VEGFR2 around the phosphorylation site of tyrosine 1175 (K-D-YP-I-V). Pathway: Receptors, Kinase/Phosphatases
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
Lamalice L, et al. (2004). Oncogene.23(2): 434-445. Takahashi T, et al. (2001). EMBO J.20(11): 2768-2778.
ncbi acc num :
NP_002244.1
ncbi gb acc num :
NM_002253.2
ncbi mol weight :
79,634 Da
ncbi pathways :
Angiogenesis Pathway 198772!!Axon Guidance Pathway 105688!!Cardiac Progenitor Differentiation Pathway 712094!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Developmental Biology Pathway 477129!!EPH-Ephrin Signaling Pathway 1016174!!EPHA-mediated Growth Cone Collapse Pathway 1016175!!Endocytosis Pathway 102279!!Endocytosis Pathway 102181
ncbi summary :
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]