Insulin B Chain Antibody | MyBioSource MBS857374 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Insulin B Chain Antibody

catalog :

MBS857374

quantity :

0.1 mL

price :

280 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS857374

products type :

Antibody

products full name :

Insulin B Chain Antibody

products short name :

[Insulin B Chain]

other names :

[insulin preproprotein; Insulin; insulin; insulin]

products gene name :

[INS]

other gene names :

[INS; INS; IDDM; ILPR; IRDN; IDDM1; IDDM2; MODY10]

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

110

specificity :

This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to the residues of human ALP.

purity :

Immunogen affinity purified

form :

1*TBS (pH7.4), 0.5%BSA, 25% Glycerol.

concentration :

100ul, 0.53mg/ml

storage stability :

Store at +4 degree C after thawing. Aliquot store at-20 degree C or-80 degree C. Avoid repeated freeze/thaw cycles.

tested application :

ELISA (EIA)

app notes :

ELISA: 1:500

image1 heading :

Testing Data

other info1 :

Preservative: 0.05% Sodium Azide. Cellular Localization: Secreted. Source Note: This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to human insulin B chain.

other info2 :

Positive Control: Recombinannt Human Insulin B Chain

products description :

Insulin is a hormone with extensive effects on both metabolism and several other body systems. It causes most of the body's celis to take up glucose from the blood (including liver, muscle, and fat tissue celis), storing it as glycogen in the liver and muscle, and stops use of fat as an energy source. Insulin is synthesized as a precursor molecule, proinsulin, which is processed prior to its secretion. Aand B-peptides are joined together by a disulfide bond to form insulin, while the central portion of the precursor molecule is cleaved and released as the C-peptide.

products references :

1. Ezra E., Blacher R., Udenfriend S.; "Purification and partial sequencing of human placental alkaline phosphatase."; Biochem. Biophys. Res. Commun. 116:1076-1083(1983). 2. Garattini E., Hua J.-C., Pan Y.C.E., Udenfriend S.; "Human liver alkaline phosphatase, purification and partial sequencing: homology with the placental isozyme."; Arch. Biochem. Biophys. 245:331-337(1986).

ncbi gi num :

4557671

ncbi acc num :

NP_000198.1

ncbi gb acc num :

NM_000207.2

uniprot acc num :

P01308

ncbi mol weight :

12kDa

ncbi pathways :

AGE/RAGE Pathway (698754); ATF-2 Transcription Factor Network Pathway (138006); Adipogenesis Pathway (198832); Aldosterone-regulated Sodium Reabsorption Pathway (130626); Aldosterone-regulated Sodium Reabsorption Pathway (130590); Amyloids Pathway (366238); Arf6 Trafficking Events Pathway (137954); Cardiac Progenitor Differentiation Pathway (712094); Developmental Biology Pathway (477129); Disease Pathway (530764)

ncbi summary :

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

uniprot summary :

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

size1 :

0.1 mL

price1 :

280 USD

more info or order :

MyBioSource product webpage

company information

MyBioSource

P.O. Box 153308
San Diego, CA 92195-3308

sales@mybiosource.com

https://www.mybiosource.com

1-888-627-0165

headquarters: USA

MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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