product summary
request information :
company name :
MyBioSource
product type :
antibody
product name :
PKC delta (Phospho-Ser645) Antibody
catalog :
MBS857345
quantity :
0.05 mg
price :
225 USD
clonality :
polyclonal
host :
rabbit
reactivity :
rat, mouse, human
application :
western blot, immunohistochemistry
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS857345
products type :
Antibody
products full name :
PKC delta (Phospho-Ser645) Antibody
products short name :
PKC delta
products name syn :
PKCd (Phospho-Ser645) Antibody
other names :
protein kinase C delta type; Protein kinase C delta type; protein kinase C delta type; protein kinase C delta VIII; tyrosine-protein kinase PRKCD; protein kinase C, delta; Tyrosine-protein kinase PRKCD (EC:2.7.10.2); nPKC-deltaCleaved into the following 2 chains:Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunitAlternative name(s):Sphingosine-dependent protein kinase-1; SDK1
products gene name :
PKC
other gene names :
PRKCD; PRKCD; MAY1; PKCD; CVID9; nPKC-delta; SDK1
uniprot entry name :
KPCD_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
676
specificity :
PKCdelta (phospho-Ser645) antibody detects endogenous levels of PKCdelta only when phosphorylated at serine 645.
purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation
form :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
concentration :
50ug/50ul
storage stability :
Store at -20 degree C for 1 year
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:500~1:1000, IHC: 1:50~1:100
other info2 :
Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human PKCdelta around the phosphorylation site of serine 645 (R-L-SP-Y-S). Pathway: MAPK, Cancer/Apoptosis, Cytoskeletal/Adhesion, Kinase/Phosphatases
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
Kei Sakamoto, et,al. (2003) Am J Physiol Endocrinol Metab ; 285: E1081 - E1088. Ling Zhang, et,al. (2004) J. Biol. Chem ; 279: 28315 - 28319. Kristof Van Kolen et,al. (2006) FEBS J ; 273: 1843 - 1854. Martin Villalba, et,al. (2002) J. Cell Biol ; 157: 253.
ncbi gi num :
31377782
ncbi acc num :
NP_006245.2
ncbi gb acc num :
NM_006254.3
uniprot acc num :
Q05655
ncbi mol weight :
80,953 Da
ncbi pathways :
AGE/RAGE Pathway 698754!!Alpha-synuclein Signaling Pathway 137913!!Alpha6-Beta4 Integrin Signaling Pathway 198807!!Apoptosis Pathway 105648!!Apoptotic Cleavage Of Cellular Proteins Pathway 105678!!Apoptotic Execution Phase Pathway 105677!!B Cell Receptor Signaling Pathway 198909!!BDNF Signaling Pathway 712093!!Ca-dependent Events Pathway 106497!!CaM Pathway 106468
ncbi summary :
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
size :
0.05 mg
price :
225 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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