catalog number :
MBS857338
products full name :
Tau (Phospho-Thr212) Antibody
products short name :
Tau
other names :
microtubule-associated protein tau isoform 6; Microtubule-associated protein tau; microtubule-associated protein tau; PHF-tau; paired helical filament-tau; neurofibrillary tangle protein; microtubule-associated protein tau, isoform 4; protein phosphatase 1, regulatory subunit 103; G protein beta1/gamma2 subunit-interacting factor 1; microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau
other gene names :
MAPT; MAPT; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103; MAPTL; MTBT1; TAU; PHF-tau
uniprot entry name :
TAU_HUMAN
reactivity :
Human, Mouse, Rat
specificity :
Tau (phospho-Thr212) antibody detects endogenous levels of Tau only when phosphorylated at threonine 212.
purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation
form :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
concentration :
50ug/50ul
storage stability :
Store at -20 degree C for 1 year
tested application :
Western Blot (WB)
app notes :
WB: 1:500~1000
other info2 :
Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human Tau around the phosphorylation site of threonine 212 (S-R-TP-P-S). Pathway: Neuroscience
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
Magnani E,et al.(2007)EMBO J.26(21):4546-54. Perez M, et al.(2007)J Neurochem.103(4):1447-60. Rhein V, et al. (2007)Arch Physiol Biochem.113(3):131-41.
ncbi acc num :
NP_001116538.2
ncbi gb acc num :
NM_001123066.3
ncbi mol weight :
80,941 Da
ncbi pathways :
Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Alzheimers Disease Pathway 672448!!Apoptosis Pathway 105648!!Apoptotic Cleavage Of Cellular Proteins Pathway 105678!!Apoptotic Execution Phase Pathway 105677!!BDNF Signaling Pathway 712093!!Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway 105679!!IL-2 Signaling Pathway 198885!!IL-6 Signaling Pathway 198864
ncbi summary :
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]