BIM(Phospho-Ser69/65) Antibody | MyBioSource MBS857256 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

BIM(Phospho-Ser69/65) Antibody

catalog :

MBS857256

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS857256

products type :

Antibody

products full name :

BIM(Phospho-Ser69/65) Antibody

products short name :

BIM

other names :

bcl-2-like protein 11 isoform 11; Bcl-2-like protein 11; bcl-2-like protein 11; bcl-2 interacting protein Bim; bcl-2-related ovarian death agonist; bcl-2 interacting mediator of cell death; BCL2-like 11 (apoptosis facilitator); Bcl2-interacting mediator of cell death

products gene name :

BIM

other gene names :

BCL2L11; BCL2L11; BAM; BIM; BOD; BIM; Bcl2-L-11

uniprot entry name :

B2L11_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

108

specificity :

BIM (phospho-Ser65) antibody detects endogenous levels of BIM only when phosphorylated at serine 65.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

50ug/50ul

storage stability :

Store at -20 degree C for 1 year

tested application :

Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

IHC: 1:50~1:100

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from mouse BIM around the phosphorylation site of serine 65 (P-A-SP-P-G). Pathway: Akt, Cancer/Apoptosis

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Fukazawa H, et al. (2004) Mol Cancer Ther ; 3(10): 1281-1288. Luciano F, et al. (2003) Oncogene ; 22(43): 6785-6793

ncbi gi num :

323362959

ncbi acc num :

NP_001191035.1

ncbi gb acc num :

NM_001204106.1

uniprot acc num :

O43521

ncbi mol weight :

8,523 Da

ncbi pathways :

Activation Of BH3-only Proteins Pathway (105658); Activation Of BIM And Translocation To Mitochondria Pathway (105662); Apoptosis Pathway (198797); Apoptosis Pathway (105648); Apoptosis Modulation And Signaling Pathway (198822); B Cell Receptor Signaling Pathway (198909); BDNF Signaling Pathway (712093); BH3-only Proteins Associate With And Inactivate Anti-apoptotic BCL-2 Members Pathway (105664); Cell Death Signalling Via NRAGE, NRIF And NADE Pathway (106443); DNA Damage Response (only ATM Dependent) Pathway (198827)

ncbi summary :

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]

uniprot summary :

BIM: a pro-apoptotic member of the BCL-2 protein family. Interacts with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and act as an apoptotic activator. Its expression can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role in neuronal and lymphocyte apoptosis. Transgenic studies in the mouse suggested that this protein functions as an essential initiator of the apoptosis in thymocyte-negative selection. Nineteen alternatively spliced transcript variants of this gene have been reported. Protein type: Apoptosis. Chromosomal Location of Human Ortholog: 2q13. Cellular Component: microtubule; mitochondrial outer membrane; extrinsic to membrane; endomembrane system; cytosol. Molecular Function: protein binding; microtubule binding. Biological Process: nerve growth factor receptor signaling pathway; apoptosis; positive regulation of apoptosis; cell-matrix adhesion; myeloid cell homeostasis; pigmentation during development; B cell apoptosis; ear development; positive regulation of caspase activity; cellular process regulating host cell cycle in response to virus; positive regulation of apoptosis by virus; mammary gland development; B cell homeostasis; positive regulation of neuron apoptosis; T cell homeostasis; kidney development; post-embryonic organ morphogenesis; spleen development; caspase activation; thymus development; positive regulation of protein homooligomerization; in utero embryonic development; male gonad development; positive regulation of cell cycle; regulation of organ growth; lumen formation; odontogenesis of dentine-containing teeth; DNA damage response, signal transduction resulting in induction of apoptosis; regulation of pigmentation during development; spermatogenesis; brain development

size1 :

0.1 mg

price1 :

215 USD

size2 :

0.05 mg

price2 :

225

more info or order :

MyBioSource product webpage