PLC gamma 1 (Phospho-Tyr783) Antibody | MyBioSource MBS857171 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PLC gamma 1 (Phospho-Tyr783) Antibody

catalog :

MBS857171

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS857171

products type :

Antibody

products full name :

PLC gamma 1 (Phospho-Tyr783) Antibody

products short name :

PLC gamma 1

products name syn :

PLCg1 (Phospho-Tyr783) Antibody

other names :

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; PLC-148; PLC-gamma-1; phospholipase C-II; phospholipase C-148; phosphoinositidase C; phospholipase C-gamma-1; inositoltrisphosphohydrolase; phosphoinositide phospholipase C; phosphatidylinositol phospholipase C; triphosphoinositide phosphodiesterase; phosphoinositide phospholipase C-gamma-1; monophosphatidylinositol phosphodiesterase; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; phospholipase C, gamma 1 (formerly subtype 148); 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; phospholipase C, gamma 1; PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1

products gene name :

PLC gamma 1

other gene names :

PLCG1; PLCG1; PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1; PLC1; PLC-II; PLC-gamma-1

uniprot entry name :

PLCG1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

1291

specificity :

PLCgamma1 (phospho-Tyr783) antibody detects endogenous levels of PLCgamma1 only when phosphorylated at tyrosine 783.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

50ug/50ul

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB)

app notes :

WB: 1:500~1:1000

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human PLCgamma1 around the phosphorylation site of tyrosine 783 (G-F-YP-V-E). Pathway: NF-kappa B, Receptors, Kinase/Phosphatases

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

DeBell KE, et al. Mol Cell Biol. 1999 Nov; 19(11): 7388-7398. Ver- MC, et al. Mol Cell Biol. 2001 Oct; 21(20): 6939-6950. Sette C, et al. EMBO J. 2002 Oct 15; 21(20): 5386-5395.

ncbi gi num :

33598948

ncbi acc num :

NP_002651.2

ncbi gb acc num :

NM_002660.2

uniprot acc num :

P19174

ncbi mol weight :

148,660 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Angiogenesis Pathway (198772); Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway (576249); Antiviral Mechanism By IFN-stimulated Genes Pathway (530760); Axon Guidance Pathway (105688); B Cell Receptor Signaling Pathway (198909); BDNF Signaling Pathway (712093); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Cell Surface Interactions At The Vascular Wall Pathway (106062)

ncbi summary :

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

PLCG1: a calcium dependent phosphatidylinositol-specific phospholipase C. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylated and activated by tyrosine kinases in response to signaling through a variety of growth factor receptors and immune system receptors. Protein type: Phospholipase; Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 20q12-q13.1. Cellular Component: signalosome; ruffle; cell projection; lamellipodium; cytoplasm; plasma membrane; intercellular junction; cytosol. Molecular Function: protein binding; glutamate receptor binding; neurotrophin TRKA receptor binding; receptor signaling protein activity; calcium ion binding; receptor tyrosine kinase binding; protein kinase binding; phospholipase C activity; phosphoinositide phospholipase C activity. Biological Process: epidermal growth factor receptor signaling pathway; axon guidance; cell migration; inositol phosphate metabolic process; fibroblast growth factor receptor signaling pathway; activation of MAPKK activity; nerve growth factor receptor signaling pathway; viral reproduction; phospholipid catabolic process; in utero embryonic development; cytokine and chemokine mediated signaling pathway; positive regulation of blood vessel endothelial cell migration; calcium-mediated signaling; signal transduction; T cell receptor signaling pathway; positive regulation of angiogenesis; phospholipase C activation; innate immune response; positive regulation of release of sequestered calcium ion into cytosol; vascular endothelial growth factor receptor signaling pathway; blood coagulation; leukocyte migration

size1 :

0.1 mg

price1 :

215 USD

size2 :

0.05 mg

price2 :

225

more info or order :

MyBioSource product webpage