GM-CSF-R-alpha (CD116) Antibody | MyBioSource MBS857146 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

GM-CSF-R-alpha (CD116) Antibody

catalog :

MBS857146

quantity :

0.1 mL

price :

290 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS857146

products type :

Antibody

products full name :

GM-CSF-R-alpha (CD116) Antibody

products short name :

GM-CSF-R-alpha

other names :

granulocyte-macrophage colony-stimulating factor receptor subunit alpha; Granulocyte-macrophage colony-stimulating factor receptor subunit alpha; granulocyte-macrophage colony-stimulating factor receptor subunit alpha; GMR-alpha; GM-CSFRalpha; GMCSFR-alpha; GM-CSF-R-alpha; colony stimulating factor 2 receptor alpha chain; colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage); CD_antigen: CD116

other gene names :

Csf2ra; Csf2ra; CD116; Csfgmra; GM-CSFR; GM-CSF-Ra; Csfgmra; GM-CSF-R-alpha; GMCSFR-alpha; GMR-alpha

uniprot entry name :

CSF2R_MOUSE

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Mouse

sequence length :

388

specificity :

This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to a region of N-terminal residues of mouse GM-CSF-R-alpha.

purity :

Immunogen Affinity purified

form :

Liquid

concentration :

100ul, 0.48mg/ml

storage stability :

Store at 4 degree C after thawing. Aliquot store at -20 degree C or -80 degree C. Avoid repeated freeze / thaw cycles.

tested application :

Western Blot (WB) , Immunocytochemistry (ICC)

app notes :

WB: 1:1000

other info1 :

Project ID: R080413

other info2 :

Positive Control: F9. Cellular Localization: Cell membrane. Storage Buffer: 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol. Preservative: 0.05% Sodium Azide.

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products description :

Background: The granulocyte macrophage -colony-stimulating factor receptor (GM-CSF-R) is a heterodimer composed of 2 subunits, alpha and beta, and ligand binding to the high-affinity receptor leads to signalling for the multiple actions of GM-CSF on target cells. The GM-CSF receptors are found on the surface of myeloid precursors, granulocytes, mononuclear phagocyte, and also frequently present on the myeloid malignancies. The GM-CSF-R-alpha transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.

products references :

1. Lanza F, Moretti S, Papa S, et al. Report on the fifth interna tional workshop on human leukocyte differentiation antigens. Boston, November 3 -7, 1993, Haematologica, 1994,79:374~386. 2. Lanza F, Castagnar B, Rigolin G, et al. Flow cytometry measurement of GM-CSF receptors in acute leukemic blasts, and normal hemopoietic cells. Leukem ia, 1997, 11: 1700~1710. 3. Jubinsky P T, Laurie A S, Nathan D G, et al. Expression and function of the human granulocyte-macrophage colony-stimulating factor receptor alpha sub unit. Blood, 1994, 84:4174~4185

ncbi gi num :

160707973

ncbi acc num :

NP_034100.2

ncbi gb acc num :

NM_009970.2

uniprot acc num :

Q00941

ncbi mol weight :

70/42kDa

ncbi pathways :

Cytokine Signaling In Immune System Pathway (970814); Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460); Hematopoietic Cell Lineage Pathway (83275); Hematopoietic Cell Lineage Pathway (489); Immune System Pathway (971216); Interleukin Receptor SHC Signaling Pathway (1001289); Interleukin-2 Signaling Pathway (971125); Interleukin-3, 5 And GM-CSF Signaling Pathway (1001290); Jak-STAT Signaling Pathway (83274)

uniprot summary :

CSF2RA: Low affinity receptor for granulocyte-macrophage colony- stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4). A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Belongs to the type I cytokine receptor family. Type 5 subfamily. 8 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, cytokine. Cellular Component: membrane; integral to membrane. Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity. Disease: Surfactant Metabolism Dysfunction, Pulmonary, 4

size1 :

0.1 mL

price1 :

290 USD

more info or order :

MyBioSource product webpage