LPA receptor 1 Antibody | MyBioSource MBS857126 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

LPA receptor 1 Antibody

catalog :

MBS857126

quantity :

0.1 mL

price :

290 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS857126

products type :

Antibody

products full name :

LPA receptor 1 Antibody

products short name :

LPA receptor 1

other names :

lysophosphatidic acid receptor 1; Lysophosphatidic acid receptor 1; lysophosphatidic acid receptor 1; LPA-1; LPA receptor 1; lysophosphatidic acid receptor Edg-2; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2; lysophosphatidic acid receptor 1; Lysophosphatidic acid receptor Edg-2

other gene names :

Lpar1; Lpar1; Edg2; Edg2; Gpcr91; Lpa1; LPA receptor 1; LPA-1

uniprot entry name :

LPAR1_RAT

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Mouse

sequence length :

364

specificity :

This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to mouse LPA- receptor I.

purity :

Affinity purified

form :

1*TBS (pH7.4), 0.5%BSA, 25%Glycerol. Preservative: 0.05% Sodium Azide.

storage stability :

Store at 4 degree C after thawing. Aliquot store at -20 degree C or -80 degree C. Avoid repeated freeze / thaw cycles.

tested application :

Western Blot (WB)

app notes :

WB: 1:1,000

other info2 :

Cellular Localization: Cell membrane

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products description :

Background: Lysophosphatidic acid receptor 1 also known as LPAR1 is a gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule lysophosphatidic acid (LPA). The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Alternative splicing of this gene has been observed and two transcript variants have been described, each encoding identical proteins.

products references :

1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004). 2. "A rat G protein-coupled receptor selectively expressed in myelin-forming cells." Allard J., Barron S., Diaz J., Lubetzki C., Zalc B., Schwartz J.-C., Sokoloff P. Eur. J. Neurosci. 10:1045-1053(1998)

ncbi gi num :

16758816

ncbi acc num :

NP_446388.1

ncbi gb acc num :

NM_053936.3

uniprot acc num :

P61794

ncbi mol weight :

41kDa

ncbi pathways :

Class A/1 (Rhodopsin-like Receptors) Pathway (1010164); G Alpha (i) Signalling Events Pathway (1010195); G Alpha (q) Signalling Events Pathway (1010197); GPCR Downstream Signaling Pathway (1010193); GPCR Ligand Binding Pathway (1010163); Gap Junction Pathway (83464); Gap Junction Pathway (483); Gastrin-CREB Signalling Pathway Via PKC And MAPK (1010213); Lysosphingolipid And LPA Receptors Pathway (1010186); Myometrial Relaxation And Contraction Pathways (198465)

ncbi summary :

G-protein coupled receptor for lysophosphatidic acid (LPA); may mediate LPA induced increase in intracellular calcium ion concentration [RGD, Feb 2006]

uniprot summary :

LPAR1: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1. Cellular Component: cell surface; endocytic vesicle; cytoplasm; dendritic spine; plasma membrane; integral to membrane; dendritic shaft. Molecular Function: G-protein coupled receptor activity; G-protein alpha-subunit binding; phospholipid binding; PDZ domain binding. Biological Process: myelination; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of I-kappaB kinase/NF-kappaB cascade; neurogenesis; positive regulation of MAPKKK cascade; activation of MAPK activity; positive regulation of apoptosis; positive regulation of Rho protein signal transduction; bleb formation

size1 :

0.1 mL

price1 :

290 USD

more info or order :

MyBioSource product webpage