product summary
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company name :
MyBioSource
product type :
antibody
product name :
CK-18 Antibody
catalog :
MBS857101
quantity :
0.1 mL
price :
290 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
19-Jun
reactivity :
mouse, rat
application :
western blot
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS857101
products type :
Antibody
products full name :
CK-18 Antibody
products short name :
CK-18
other names :
keratin, type I cytoskeletal 18; Keratin, type I cytoskeletal 18; keratin, type I cytoskeletal 18; CK-18; Endo B; keratin D; keratin-18; cytokeratin-18; cytokeratin endo B; keratin complex 1, acidic, gene 18; keratin 18; Cytokeratin endo B; Keratin D; Cytokeratin-18; CK-18; Keratin-18; K18
products gene name :
CK-18
other gene names :
Krt18; Krt18; K18; CK18; Krt1-18; Kerd; Krt1-18; Keratin D; CK-18; K18
uniprot entry name :
K1C18_MOUSE
clonality :
Polyclonal
isotype :
IgG
clone :
19-Jun
host :
Rabbit
reactivity :
Mouse, Rat
sequence length :
423
specificity :
This antibody is produced by immunizing mouse with a synthetic peptide (KLH-coupled) corresponding to near C-terminal residues of CK18.
form :
Mouse Monoclonal IgG2a in 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol. Preservative: 0.05% Sodium Azide.
storage stability :
Store at 4 degree C after thawing. Aliquot store at -20 degree C or -80 degree C. Avoid repeated freeze / thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB: 1:25,000-50,000
other info2 :
Cellular Localization: Cytoplasm, Nucleus domain
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products description :
Background: Cytokeratin 18 is an acidic keratin which is found primarily in non squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas but not in squamous cell carcinomas. Cytokeratin 18 exists in combination with Cytokeratin 8, a basic keratin. Hepatocellular carcinomas have been reportedly defined by the use of antibodies that recognize only Cytokeratins 8 and 18.
products references :
1. Singer P.A., Trevor K., Oshima R.G. J. Biol. Chem. 261:538-547(1986). 2. Ichinose Y., Morita T., Zhang F. etc. Gene 70:85-95(1988). 3. Dixon M.J., Robinson V., White A., Ferguson M.W. J. Anat. 183:423-438(1993).
ncbi gi num :
254540068
ncbi acc num :
NP_034794.2
ncbi gb acc num :
NM_010664.2
uniprot acc num :
P05784
ncbi mol weight :
48kDa
ncbi pathways :
EGFR1 Signaling Pathway (198278)
uniprot summary :
K18: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 18 and its filament partner keratin 8 are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Defects are a cause of cryptogenic cirrhosis. Protein type: Nucleolus; Cytoskeletal. Cellular Component: cytoplasm; keratin filament; microtubule organizing center; intermediate filament; nucleus. Molecular Function: protein binding; structural molecule activity. Biological Process: tumor necrosis factor-mediated signaling pathway; intermediate filament cytoskeleton organization and biogenesis; negative regulation of apoptosis; Golgi to plasma membrane CFTR protein transport
size1 :
0.1 mL
price1 :
290 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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