Src (Phospho-Tyr418) Antibody | MyBioSource MBS857078 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Src (Phospho-Tyr418) Antibody

catalog :

MBS857078

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS857078

products type :

Antibody

products full name :

Src (Phospho-Tyr418) Antibody

products short name :

Src

other names :

proto-oncogene tyrosine-protein kinase Src; Proto-oncogene tyrosine-protein kinase Src; proto-oncogene tyrosine-protein kinase Src; proto-oncogene c-Src; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; protooncogene SRC, Rous sarcoma; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; SRC proto-oncogene, non-receptor tyrosine kinase; Proto-oncogene c-Src; pp60c-src; p60-Src

products gene name :

Src

other gene names :

SRC; SRC; ASV; SRC1; c-SRC; p60-Src; SRC1; p60-Src

uniprot entry name :

SRC_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

536

specificity :

Src (phospho-Tyr418) antibody detects endogenous levels of Src only when phosphorylated at tyrosine 418.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

50ug/50ul

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:500~1:1000, IHC: 1:50~1:100

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human Src around the phosphorylation site of tyrosine 418 (N-E-YP-T-A). Pathway: Cancer/Apoptosis, MAPK, Cytoskeletal/Adhesion, Wnt/beta-catenin

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Dufilho M, et al. (2005) J Biol Chem. 280(43):35999-36006. Sanders MA, et al. (2005) J Biol Chem. 280(25): 23516-23522. Murugappan S, et al. (2005) Blood. 106(2):550-557. Gu JJ, et al. (2005) Blood. 105(8): 3270-3277.

ncbi gi num :

4885609

ncbi acc num :

NP_005408.1

ncbi gb acc num :

NM_005417.4

uniprot acc num :

P12931

ncbi mol weight :

60,589 Da

ncbi pathways :

ADP Signalling Through P2Y Purinoceptor 1 Pathway (161061); AGE/RAGE Pathway (698754); Adaptive Immune System Pathway (366160); Adherens Junction Pathway (83070); Adherens Junction Pathway (481); AhR Pathway (755436); Alpha-synuclein Signaling Pathway (137913); Alpha6-Beta4 Integrin Signaling Pathway (198807); Androgen Receptor Signaling Pathway (198806); Angiogenesis Pathway (198772)

ncbi summary :

This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

Src: proto-oncogenic cytoplasmic tyrosine kinase of the SRC family. Highly expressed in certain fully differentiated cells such as neurons, platelets and macrophages. Phosphorylation of an activation loop tyrosine activates the enzyme; phosphorylation of a tyrosine in the C-terminus by Csk inhibits the enzyme. Two alternatively spliced isoforms have been described. Protein type: Oncoprotein; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Kinase, protein; Protein kinase, TK; TK group; Src family. Chromosomal Location of Human Ortholog: 20q12-q13. Cellular Component: neuron projection; mitochondrion; lysosome; postsynaptic density; actin filament; caveola; cytosol; extrinsic to internal side of plasma membrane; perinuclear region of cytoplasm; mitochondrial inner membrane; late endosome; cytoplasm; plasma membrane; nucleus. Molecular Function: protein C-terminus binding; ephrin receptor binding; non-membrane spanning protein tyrosine kinase activity; phosphoprotein binding; insulin receptor binding; protein kinase activity; integrin binding; protein binding; enzyme binding; protein kinase C binding; SH3/SH2 adaptor activity; protein-tyrosine kinase activity; heme binding; estrogen receptor binding; kinase activity; SH2 domain binding; ATP binding; hormone receptor binding; receptor binding. Biological Process: oogenesis; regulation of estrogen receptor signaling pathway; progesterone receptor signaling pathway; estrogen receptor signaling pathway; central nervous system development; positive regulation of cyclin-dependent protein kinase activity; nerve growth factor receptor signaling pathway; viral reproduction; positive regulation of apoptosis; regulation of cell cycle; positive regulation of transcription, DNA-dependent; uterus development; negative regulation of mitochondrial depolarization; negative regulation of protein homooligomerization; positive regulation of MAP kinase activity; cell-cell adhesion; transforming growth factor beta receptor signaling pathway; cell adhesion; response to electrical stimulus; bone resorption; response to drug; platelet activation; fibroblast growth factor receptor signaling pathway; activation of protein kinase B; response to virus; transcytosis; positive regulation of integrin activation; positive regulation of protein amino acid autophosphorylation; cellular response to insulin stimulus; response to mechanical stimulus; T cell costimulation; regulation of vascular permeability; negative regulation of transcription, DNA-dependent; leukocyte migration; negative regulation of apoptosis; axon guidance; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; platelet-derived growth factor receptor signaling pathway; negative regulation of caspase activity; positive regulation of smooth muscle cell migration; signal transduction; regulation of cell-cell adhesion; forebrain development; ephrin receptor signaling pathway; integrin-mediated signaling pathway; response to nutrient levels; epidermal growth factor receptor signaling pathway; regulation of bone resorption; negative regulation of focal adhesion formation; positive regulation of phosphoinositide 3-kinase activity; signal complex assembly; response to mineralocorticoid stimulus; cell cycle; regulation of cell proliferation; cell proliferation; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; response to hydrogen peroxide; regulation of protein binding; Ras protein signal transduction; stress fiber formation; innate immune response; response to acidity; positive regulation of insulin receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; blood coagulation; positive regulation of cytokine secretion

size1 :

0.1 mg

price1 :

215 USD

size2 :

0.05 mg

price2 :

225

more info or order :

MyBioSource product webpage