antibody

NF kappa B-p105/p50 (Ab-932) Antibody

MBS856956

0.05 mg

180 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, immunohistochemistry

Antibody

NF kappa B-p105/p50 (Ab-932) Antibody

NF kappa B-p105/p50

NFkB-p105/p50 (Ab-932) Antibody

nuclear factor NF-kappa-B p105 subunit isoform 2; Nuclear factor NF-kappa-B p105 subunit; nuclear factor NF-kappa-B p105 subunit; NF-kappabeta; DNA binding factor KBF1; DNA-binding factor KBF1; nuclear factor NF-kappa-B p50 subunit; nuclear factor kappa-B DNA binding subunit; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; DNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1Cleaved into the following chain:Nuclear factor NF-kappa-B p50 subunit

NFKB1; NFKB1; p50; KBF1; p105; EBP-1; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B

NFKB1_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

968

NFkappaB-p105/p50 (Ab-932) antibody detects endogenous levels of total NFkappaB-p105/p50 protein.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

50ug/50ul

Store at -20 degree C for 1 year

Western Blot (WB), Immunohistochemistry (IHC)

WB: 1:500~1:1000, IHC: 1:50-1:100

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human NFkappaB-p105/p50 around the phosphorylation site of serine 932 (E-T-SP-F-R). Pathway: NF-kappa B, Akt, Cancer/Apoptosis, Chromatin/Transcription

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

Sören Beinke et al. (2004) Biochem J. 382(Pt 2): 393 -409. Vigo Heissmeyer1, et al. (1999) The EMBO Journal 18: 4766 -4778,. F Chen, et al. (2006) Cell Death and Differentiation 13: 1835 -1838. Kris A. Steinbrecher, et al. (2005) Mol Cell Biol. 25(19): 8444 -8455.

259155302

NP_001158884.1

NM_001165412.1

P19838

85,520 Da

AGE/RAGE Pathway 698754!!Activated TLR4 Signalling Pathway 106400!!Activation Of NF-kappaB In B Cells Pathway 576251!!Acute Myeloid Leukemia Pathway 83117!!Acute Myeloid Leukemia Pathway 529!!Adaptive Immune System Pathway 366160!!Adipocytokine Signaling Pathway 83093!!Adipocytokine Signaling Pathway 505!!Alternative NF-kappaB Pathway 138004!!Amoebiasis Pathway 167324

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

0.05 mg

180 USD