LGR5 Antibody | MyBioSource MBS856950 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

LGR5 Antibody

catalog :

MBS856950

quantity :

0.1 mL

price :

290 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS856950

products type :

Antibody

products full name :

LGR5 Antibody

products short name :

LGR5

other names :

leucine-rich repeat-containing G-protein coupled receptor 5 isoform 2; Leucine-rich repeat-containing G-protein coupled receptor 5; leucine-rich repeat-containing G-protein coupled receptor 5; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38; orphan G protein-coupled receptor HG38; leucine-rich repeat-containing G protein-coupled receptor 5; leucine-rich repeat containing G protein-coupled receptor 5; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38

products gene name :

LGR5

other gene names :

LGR5; LGR5; FEX; HG38; GPR49; GPR67; GRP49; GPR49; GPR67

uniprot entry name :

LGR5_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

883

specificity :

This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to a region of LGR5.

purity :

Immunogen affinity purified

form :

Liquid

storage stability :

Store at 4 degree C after thawing. Aliquot store at -20 degree C or -80 degree C. Avoid repeated freeze / thaw cycles.

tested application :

Western Blot (WB), Immunocytochemistry (ICC)

app notes :

WB: 1:1,000-1:2,000, ICC: 1:50

other info1 :

Product Type: Rabbit Polyclonal IgG, primary Ab. Positive Control: F9, NCCIT. Cellular Localization: Cell membrane Cell nucleus

other info2 :

Immunogen: affinity purified. Storage Buffer: 1*TBS (pH7.4), 0.5%BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products description :

G-protein coupled receptor GPR49 (also known as Leucine -rich repeat -containing G -protein coupled receptor 5, Lgr5) is a stem cell marker of the intestinal epithelium and the hair follicule. It is expressed in the gonads, the adrenal gland, and in the brain, overexpressed in cancers of the ovary, colon and liver

products references :

1. Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors."McClanahan T., Koseoglu S., Smith K., Grein J., Gustafson E., Black S., Kirschmeier P., Samatar A.A.Cancer Biol. Ther. 5:419-426(2006). 2. "Immunostaining of Lgr5, an intestinal stem cell marker, in normal and premalignant human gastrointestinal tissue."Becker L., Huang Q., Mashimo H.ScientificWorldJournal 8:1168-1176(2008)

ncbi gi num :

469608414

ncbi acc num :

NP_001264155.1

ncbi gb acc num :

NM_001277226.1

uniprot acc num :

O75473

ncbi mol weight :

95kDa

ncbi pathways :

Disease Pathway (530764); RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway (1016209); Signal Transduction Pathway (477114); Signaling By WNT In Cancer Pathway (1016191); Signaling By Wnt Pathway (106510); TCF Dependent Signaling In Response To WNT Pathway (980475); XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway (1016210); Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway (1016208); Regulation Of FZD By Ubiquitination Pathway (980483)

ncbi summary :

The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

uniprot summary :

LGR5: a leucine-rich repeat-containing G-protein-coupled receptor. Receptor for R-spondins, potent stimulators of adult stem cell proliferation. A marker of cycling, long-lived and multipotent adult stem cell populations. Target gene of Wnt signaling. A Wnt receptor component that enhances Wnt signaling by soluble R-spondin proteins. Intestinal Lgr5+ stem cells give rise throughout life to proliferation of cells in crypts, which migrate along the crypt-villus axis, differentiating into five main cell types. Wnt signaling plays a crucial role in the proliferation and differentiation of these crypt epithelial cells. Two isoforms of the human protein are produced by alternative splicing. Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR. Chromosomal Location of Human Ortholog: 12q22-q23. Cellular Component: integral to plasma membrane; plasma membrane; trans-Golgi network membrane. Molecular Function: G-protein coupled receptor activity; protein binding; transmembrane receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; inner ear development

size1 :

0.1 mL

price1 :

290 USD

more info or order :

MyBioSource product webpage